通過新型無機奈米團簇再生琺瑯質

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Title:	通過新型無機奈米團簇再生琺瑯質 Regeneration of Tooth Enamel by Novel Inorganic Nanoclusters
Authors:	邱昱太 CHIOU, YU-TAI
Contributors:	奈米醫學工程研究所碩士班郭聰榮陳志華
Keywords:	琺瑯質;無機團簇 Enamel;inorganic cluster
Date:	2021-06-18
Issue Date:	2022-01-05
Abstract:	琺瑯質的再生是一個非常難的挑戰，因為它具有複雜的結構而且還沒被人為複製出來。在本研究中，我們使用了一種由鈣磷酸離子簇所組成的新型無機材料，他可以創建前體層來誘導琺瑯質的生長來達到修復琺瑯質的表面。所以我們的目的是使用這種可以去除小有機物來穩定的材料無機團簇來修復琺瑯質。在這項研究中，我們使用維式硬度來檢查我們蝕刻琺瑯質後的硬度，我們發現硬度值低於未蝕刻的硬度值。所以，我們證明了我們可以模擬自然界中琺瑯質的損壞情況。所以我們會一半的琺瑯質表面塗上指甲油來保護表面不被收蝕刻，剩下的區域用無機團簇進行修復。我們發現硬度值已增加到我們蝕刻琺瑯之前的值，此結果表明我們的材料可以再生琺瑯質的機械性能。最後，結果也證明我們的材料凝膠狀的無機團簇水溶液可以成功修復琺瑯質表面，並且新修復區域的特徵具有與天然琺瑯質幾乎相同的硬度特性。 The regeneration of enamel is a very difficult challenge because its complex structure has not been artificially copied. In this research we used a new designed material consisting of calcium phosphate ion clusters (CPIC) which can be used to create a precursor layer to induce the growth of enamel to repaired the enamel surface. So the aim is to us the material CPICs inorganic cluster that can stabilize by removable small organic substance to repaired the enamel, which can repair enamel with the original structural complexity.In this research we used the micro-hardness to check the hardness of the enamel after we etched the enamel we discovered that the value of the hardness was lower than without etched. So, we proved that we can simulation the damaged for the enamel in the nature. For comparison, half of the enamel surface was covered with the nail varnish, and the remaining area was used for repair by using CPICs. We than discover the value had increased to the value before we etching the enamel. The hardness result shows that our cluster can regenerated the mechanical property of enamel. Finally, the result proved that our material gel-like CPICs solution can successfully repaired the enamel surface and the feature of the new repair region have almost the same hardness property that the nature enamel.
Description:	碩士指導教授：郭聰榮指導教授：陳志華委員：楊正昌委員：王迪彥委員：鄭財木
Data Type:	thesis
Appears in Collections:	[Graduate Institute of Nanomedicine and Medical Engineering] Dissertations/Theses

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