Study the Neuroprotective Effect of Mangosteen Pericarp Extract and Probiotic in 6-OHDA-Induced Parkinson's Disease Rat Model

English | 正體中文 | 简体中文 | Items with full text/Total items : 45422/58598 (78%)
Visitors : 2539965 Online Users : 190

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

TMUIR > College of Nutrition > Graduate Institute of Metabolism and Obesity Sciences > Dissertations/Theses > Item 987654321/61263

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/61263

Title:	Study the Neuroprotective Effect of Mangosteen Pericarp Extract and Probiotic in 6-OHDA-Induced Parkinson's Disease Rat Model
Authors:	袁碧茹 NURRAHMA, BIRA ARUMNDARI
Contributors:	代謝與肥胖科學研究所碩士班黃惠宇
Keywords:	Parkinson’s disease;6-OHDA;probiotic;polyphenol;mangosteen pericarp
Date:	2021-06-29
Issue Date:	2022-01-02 22:22:53 (UTC+8)
Abstract:	Parkinson’s disease (PD) is the second common neurodegenerative disease in the world that impairs motor and several non-motor functions. Oxidative stress and mitochondrial dysfunction are associated with PD progression. 6-hydroxydopamine (6-OHDA) is the most frequently used neurotoxin model to study PD development as it mimics motor and several non-motor dysfunctions found in PD patients. Polyphenol rich mangosteen pericarp extract (MP) has been widely reported as potent antioxidant. Probiotics have been known to exert antioxidative properties, immunomodulator effect, and neuroprotection. Combination of probiotic and MP may increase the action of one another. This study investigated the neuroprotective effect of 8-week supplementation of low dose (LMP) and high dose (HMP) of polyphenol rich MP, and combination of LMP and probiotic Lactobacillus salivarius subsp. salicinius AP-32 (LMP+P) in 6-OHDA-induced PD rat model. Supplementation of LMP, HMP, and LMP+P prevented dopaminergic neurons loss in substantia nigra (SNc) and improved motor function in PD-like rats. This neuroprotective effect was accompanied by significant increases in the expression of antioxidant enzymes (Sod1, Sod2, Cat, GPx) and reduction of reactive oxygen species (ROS) in the brain. Further, supplementation of LMP, HMP, and LMP+P for 8 weeks prevented mitochondrial dysfunction and increased mtDNA copy number in soleus muscle. Importantly, supplementation of HMP elevated a key factor in mitochondrial biogenesis, Pgc1a, in soleus muscle. This elevation by HMP was followed by increases of mtDNA copy number and mitochondrial function in soleus muscle, and recovery of motor dysfunction. Taken together, this study shows a potential use of high dose mangosteen pericarp extract as an adjunctive therapy for PD.
Description:	碩士指導教授：黃惠宇委員：吳介信委員：黃士懿
Data Type:	thesis
Appears in Collections:	[Graduate Institute of Metabolism and Obesity Sciences] Dissertations/Theses

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	175	View/Open

View Licence

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

Loading...