表現膜抗體報告基因於糖尿鼠之胰島細胞以非侵犯性造影自體免疫型糖尿病之病程

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TMUIR > College of Pharmacy > Graduate Institute of Pharmacognosy Science > Dissertation/Thesis > Item 987654321/59456

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/59456

Title:	表現膜抗體報告基因於糖尿鼠之胰島細胞以非侵犯性造影自體免疫型糖尿病之病程 Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Image the Disease Progression of Autoimmune Diabetes
Authors:	郭文瑄 Kuo, Wun-Syuan
Contributors:	莊國祥
Keywords:	報告基因;非肥胖型糖尿病小鼠 Reporter gene;NOD mice
Date:	2015-07-16
Issue Date:	2020-08-28 14:36:43 (UTC+8)
Abstract:	非肥胖型糖尿病小鼠（Non-obese diabetic mice, NOD mice）為第一型糖尿病之常用疾病動物模式，但仍面臨無法準確地追蹤糖尿病之發病病程。為了解決此問題，實驗室已成功開發出一種於胰島β細胞專一性表現之報告基因（Reporter gene）之非肥胖型糖尿病轉殖鼠（NOD/reporter mice）。此轉殖鼠能利用專一性光學造影劑並搭配光學造影系統（Optical imaging），準確地觀察NOD/reporter mice體內胰島細胞的存活情形。我們透過研究證實此NOD/reporter mice與wild-type NOD mice胰島細胞之生理模式與病理模式並無差異；此外，透過研究確認胰島細胞表現報告基因亦不影響胰島β細胞分泌胰島素之能力。因此NOD/reporter mice未來可改善並解決wild-type NOD mice在研究上之問題且有利於第一型糖尿病之研究。 Non-obese diabetic mice (NOD mice) were animal model of the type I diabetes mellitus, but still faces many problems, such as could not accurately track the incidence of diabetes duration. In order to solve this problem, we had successfully developed a NOD/reporter mice which were specific expression reporter on the islet cells surface. NOD/reporter mice could use specific optical probe to assess the delivery of cells by optical imaging system in vivo. Herein, we showed that pathology and physiology of NOD/reporter mice were similar to wild-type NOD mice. Additionally, we also confirmed the islet β cell expressed reporter do not influence the function of secreting insulin. Therefore, NOD/reporter mice can help researchers easily tracing the disease progression of type I diabetes mellitus by noninvasive imaging systems.
Description:	碩士指導教授:莊國祥委員:鄭添祿委員:李美賢
Data Type:	thesis
Appears in Collections:	[Graduate Institute of Pharmacognosy Science] Dissertation/Thesis

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