Taipei Medical University Institutional Repository:Item 987654321/59300
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    题名: 幹樣特質的抑制會增加卵巢癌順鉑的敏感性
    Inhibition of stem-like traits increases cisplatin sensitivity in ovarian cancer
    作者: 沐罕
    Zucha, Muhammad Ary
    贡献者: 陳彥州
    关键词: 布魯頓的酪氨酸激酶(BTK);化療;腫瘤幹細胞;卵巢癌;球體;順鉑
    chemoresistance;cancer stem cell;ovarian cancer;spheroids;cisplatin
    日期: 2015-06-09
    上传时间: 2020-08-11 14:22:18 (UTC+8)
    摘要: According to a Prognoscan database, upregulation of Bruton’s tyrosine kinase (Btk) is associated with low overall survival in ovarian cancer patients. We found that spheroids-forming ovarian cancer cell, which highly expressed cancer stem-like cell (CSC) markers and Btk, were cisplatin resistant. We next treated CSCs and non-CSCs by a combination of ibrutinib and cisplatin. We found that chemoresistance was dependent on Btk and JAK2/STAT3, which maintained CSC by inducing Sox-2 and prosurvival genes. We suggest that addition of ibrutinib to cisplatin may improve treatment outcome in ovarian cancer
    描述: 博士
    指導教授:陳彥州
    委員:黃彥華
    委員:張淑芬
    委員:李明學
    数据类型: thesis
    显示于类别:[醫學科學研究所] 博碩士論文

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