| 摘要: | 二氧化鋯因為其強度、透光性與良好的生物相容性，被廣泛地使用於牙科贋復物，若能使其成為具有抗菌與抑菌性質之義齒材料，降低二次齲齒與牙周病的發生率，將能更加提升義齒之使用效益。本研究以牙科用釉料添加不同濃度之兩種奈米複合抗菌粉體(抗菌粉體A及抗菌粉體B)，分別以0.5%、1.0%、3.0%、5.0%及8.0%進行上釉燒結於牙科二氧化鋯瓷表面，探討由不同奈米複合粉體、不同濃度比例等製程參數所塗布的牙科用釉料，在抗菌性方面的表現。塗布於二氧化鋯表面之塗層將以各種檢測分析方法，包含X-ray繞射分析儀、光學顯微鏡、掃描式電子顯微鏡、能量散射光譜儀以及原子力顯微鏡，探討其晶體結構、粒徑大小與表面形貌、表面粗糙度和成分分析等，並以分光光譜儀檢測其顏色是否因上釉塗層所產生色差，最後選擇濃度為1%、5%及8.0%之試片進行抗菌試驗，試驗所使用之菌株為Streptococcus mutans及Aggregatibacter actinomycetemcomitans，係造成牙菌斑、齲齒與牙周炎之主要菌株。由抗菌試驗結果可知，單純上釉的樣品其抑菌率皆<1%；塗佈抗菌粉體之樣品其抗菌率上升至60.5%(Streptococcus mutans)和76.9%(Aggregatibacter actinomycetemcomitans)，其中又以塗布抗菌粉體B之樣品表現較佳。
Zirconium dioxide is widely used in dental prosthesis due to its excellent strength, optical property and good biocompatibility. If antibacterial properties of ZrO2 can be improved, it can be not only used as a denture material but also reduce the occurrence of secondary caries and periodontal disease. In this study, nanocomposites A and nanocomposites B with different concentrations of 0.5%. 1.0%, 3.0%, 5.0% and 8.0% were added into dental glazing materials, respectively. Both nanocomposites were glazed and sintered on the surface of dental zirconia porcelain. The dental glaze coated with different nanocomposites and different concentration ratios were investigated. The crystal structure, particle size, surface morphology, surface roughness and elemental analysis of the functional coatings will be studied by following methods, X-ray diffraction, optical microscope, scanning electron microscope, energy-dispersive X-ray spectroscopy and atomic force microscope. Moreover, the color difference caused by the functional coating was detected by spectrophotometer. Finally, the coated-sample with the concentration of 1%, 5% and 8% were selected for the antibacterial test. The colonies used in the test were Streptococcus mutans and Aggregatibacter actinomycetemcomitans, those colonies are two main causes of plaque, caries and periodontitis. According to the results of the antibacterial test, the bacteriostatic rate of the sample without functional coating was <1%; the antibacterial rate of the sample coated with the functional layer increased to 60.5% and 76.9%, respectively, and the sample coated with nanocomposite B showed the better performance. |
