血管狹窄之血流動力學和生物力學行為分析

TMUIR > College of Oral Medicine > Master Program in Medical Equipment Industry > Dissertations/Theses > Item 987654321/58844

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Title:	血管狹窄之血流動力學和生物力學行為分析 Research of hemodynamics and biomechanical behaviors on vascular vessel with stenosis
Authors:	許姈娟 HSU, LING-CHUAN
Contributors:	醫療器材產業碩士專班周幸華
Keywords:	血栓;血管造影術;電腦輔助分析法 angiography examination;blood flow;computer-aided;image processing;stenosis
Date:	2014-12-25
Issue Date:	2020-03-03 11:24:26 (UTC+8)
Abstract:	本研究目的是採用血管造影檢查和3D 電腦輔助分析法觀察狹窄血管之血流速度與血管壁應力，本研究涵蓋24 位於手臂以及心臟患有狹窄病症之自願者，而12 名志願者作為對照組比較之。36 個3D 動脈模型採用核磁共振圖像重建之，模擬血液血流動力學之行為。已經有許多相關3D 有限元模型的動脈研究，但現今尚未有研究不同狹窄厚度的動脈研究。當務之急是把病變動脈段的機械性應用於輔助治療計劃，因為血栓造成的血管壁壓力是很容易引起動脈硬化，而本研究結果也可能有預測病變發生位置的功能。結果表明1 mm 厚的狹窄降低了血流速度的 40％，並且從3D 逆向模型可確認應力最大的發生位置就在於血管壁最狹窄之位置。血流速度方面，血管造影試驗與3D 模型的結果類似，但其血流速度在血管造影試驗較3D 模型中之血流速度高。如上所述，本研究提供之血栓信息可對臨床提供診斷和治療之幫助。 The purpose of this study is to investigate the effect of stenosis on flow vector and vascular wall stress using angiographic examination and 3-D computer-aided program. Twenty-four volunteers with stenosis in hearts and arms were enrolled, and twelve volunteers were enrolled as the control group. Totally thirty-six 3-D artery models were reconstructed to simulate blood hemodynamic behaviors by magnetic resonance images. Several studies have studied 3-D finite element artery models, but few examined the effect of different stenosis thicknesses in arteries. It is imperative to incorporate mechanical properties of a diseased artery segment into treatment planning because the stress is a strong biological trigger that directs atherosclerosis protection, and this parameter may also have predictive value to pinpoint regions at risk for restenosis. The results showed that stenosis of 1 mm thickness decreased the blood flow velocity approximately 40%, and it confirmed that stenosis also induces abnormal stress in the most narrowly position of vascular wall. The results of flow vector are similar to those of angiographic test under the same stenosis thickness, but they are higher in angiographic test than those in the computer-aided model. As described above, the present study provides the information for stenosis in clinical diagnosis and treatment.
Description:	碩士指導教授：周幸華委員：林利香委員：張雍敏
Data Type:	thesis
Appears in Collections:	[Master Program in Medical Equipment Industry] Dissertations/Theses

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