心血管支架與奈米結構薄膜之生物力學行為分析

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Taipei Medical University Institutional Repository > 口腔醫學院 > 醫療器材產業碩士專班 > 博碩士論文 > Item 987654321/58400

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題名:	心血管支架與奈米結構薄膜之生物力學行為分析 Biomechanical behavior of vascular stent with nanostructured thin film
作者:	李梓槃 LEE, TZU-PAN
關鍵詞:	心血管支架;奈米鍍膜;電腦輔助分析法 biomechanics;finite element analysis;surface treatment;vascular stent;von Mises stress
日期:	2014-12-22
上傳時間:	2020-01-13 12:56:22 (UTC+8)
摘要:	本研究目的是採用3D 電腦輔助分析法觀察心血管支架於血栓部位撐開時之應力與血管壁所受到之應力，本研究的目的是觀察心血管支架加入氮化鉻（CrN）後之應力變化，3D 有限元模型採用電腦輔助分析之反向系統構成而成，於應力觀點觀察此新式奈米複合心血管支架進行生物力學之研究。本研究發現新式CrN 心血管支架之最大應力發生在網狀結構的交叉點，數據分析表明，相較於位經過表面處理之心血管支架應力減少大約12％，本結果證實奈米複合膜可提高血管支架之生物力學特性並有效降低異常之應力集中情形之發生，過大之應力於臨床上容易引發血管術後再狹窄之機率，本研究的結果顯示此新式CrN 奈米心血管支架擁有潛力於臨床醫學帶來突破。 The aim of this research was to investigate stresses resulting from different thicknesses and compositions of a chromium nitride (CrN) films at the interface between vascular stent and artery using three-dimensional finite element models (FEM). FEM models would be constructed using computer aided design system, and the effects of antibacterial nanostructured composite films in the stress field were investigated; this index has not yet been reported in vascular stent. The maximum stress in the vascular stent occurred at the position of the intersections of net-like structure. Data analysis indicated that stresses approximately decreased 12% in the case of using vascular stents with antibacterial nanostructured composite films than control group, and the stresses decreased with increasing film thicknesses. Results confirmed that the nanostructured composite films improve biomechanical properties of the vascular stents and release abnormal stress concentrations to prevent from restenosis. The results of present study offer the potential clinical benefit of inducing superior biomechanical behavior in vascular stents.
描述:	碩士指導教授-林永和委員-程瀚毅委員-歐士輔
資料類型:	thesis
顯示於類別:	[醫療器材產業碩士專班] 博碩士論文

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