| 摘要: | 前言：躁鬱症會長期影響患者的生理與心理表現，若未接受妥善治療便可能造成患者在工作、生活、健康上的困擾，又若合併感染C型肝炎，對患者的身心負擔可能會更加沉重。本研究鑒於台灣鮮少有大型的流行病學研究，針對躁鬱症患者罹患C型肝炎之可能性進行探討，因此難以得知台灣的躁鬱症患者在罹患C型肝炎上是否有所相關。
方法：本研究使用台灣全民健康保險研究資料庫之2005年百萬承保抽樣歸人檔，篩選出2011年至2013年間內之躁鬱症患者為研究對象，並且排除診斷為躁鬱症前已感染C型肝炎者，以及診斷當下年齡小於18歲者。研究期間內之躁鬱症患者為實驗組，未罹患躁鬱症者為對照組，並將性別、年齡、收入、居住地區、都市化程度做為控制變項進行研究分析。
結果：本研究實驗組與對照組依照性別、年齡進行分層抽樣後各為3544人，以條件式邏輯斯迴歸進行分析後發現，有躁鬱症的族群與C型肝炎之間呈現顯著相關(p < 0.001)，其中研究對象的收入(p < 0.001)、居住地區(p = 0.002)呈現顯著相關。
結論：由本研究結果可得知，研究對象是否罹患躁鬱症在感染C型肝炎是有相關性的，而躁鬱症病患有C型肝炎者是一般民眾的2.52倍(95% CI: 1.706- 3.728)。而得到C型肝炎的風險又會和研究對象的收入狀態、居住地區有關，月投保薪資級距超過新台幣26,401元者，和居住在南部的族群，有較高的C型肝炎感染風險。
Objective: Bipolar disorder will affect patient's long-term physiological and psychological performance. If patients do not receive proper treatment, it may create some disturbance to patients in their work, life and health. Furthermore, if patients combined with infection with hepatitis C virus, the physical and mental burden on them may be heavier. However, there is little epidemiological study in Taiwan reviewing facts and possibilities of suffering from hepatitis C virus in patients with bipolar disorder. Therefore, it is difficult to determine whether bipolar disorder patients in Taiwan are associated with hepatitis C virus or not.
Method: In our study, we use Taiwan National Health Insurance Research Database of the Longitudinal Health Insurance Database 2005 as data resources. We screened out patients who had bipolar disorder from year 2011 to 2013 as study object, also excluded patients who were infected with hepatitis C virus before the diagnosis of bipolar disorder, as well as the diagnosis of the current age of less than 18 years old. During the study period, the patients with bipolar disorder were the experimental group, and those who did not suffer from bipolar disorder were the control group. Furthermore, gender, age, income, living area and urbanization degree of patients were used as control variables.
Results: In our study, 3544 subjects were stratified by sex and age in the experimental group and the control group. By using conditional logistic regression to analyze, the results showed that there was significant correlation between the group with bipolar disorder and hepatitis C (p < 0.001). The income of the subjects (p < 0.001) and the living area (p = 0.002) were also significantly correlated.
Conclusions: According to the results of our study, it is known that the study object who suffered from bipolar disorder is in relation to the infection of hepatitis C. Moreover, bipolar disorder patients compared with general population had 2.52 times more likely to be infected with hepatitis C virus (95% CI: 1.706 - 3.728). The risk of hepatitis C virus infection is found to be related to the income status and area of residence of the study population. Group with monthly insured salary leveled more than NT $ 26,401, and population who live in the south have a higher risk of hepatitis C virus infection. |
