T1-11微球之製備與特性評估

Taipei Medical University Institutional Repository > 口腔醫學院 > 生醫材料暨組織工程研究所 > 博碩士論文 > Item 987654321/57659

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題名:	T1-11微球之製備與特性評估 Preparation and characterization of T1-11 microspheres
作者:	黃惠仙 Huang, Hui-Hsien
貢獻者:	生醫材料暨工程研究所蔡翠敏
關鍵詞:	神經性退化疾病;T1-11;微球 neurodegenerative disease;T1-11;microsphere
日期:	2011-06-28
上傳時間:	2019-06-11 12:39:27 (UTC+8)
摘要:	TI-11是一種新化學成分，從中藥天麻萃取而來，具有可以減緩神經退化性疾病的病程之能力。由於神經退化性疾病患者的運動及認知障礙，會造成臨床上常用之錠劑在用藥上較為不便，因此，設計一種經非口服途徑且長效的劑型是必須的。微球包覆技術自發展以來，一直是最重要的藥物制放系統之一，且已經應用在製藥工業上。本研究主要目的是利用PLGA包覆T1-11而成微球，藉由微球包覆技術，使T1-11能達到長效釋放。本研究利用不同性質之PLGA以w/o/w方式進行包覆，藉由改變製備參數，評估各項條件對微球特性之影響。在電子顯微鏡下，T1-11微球呈圓球狀，但表面會有孔洞結構。全部配方之微球的平均粒徑皆在5~45 μm之間，且隨著PVA濃度增加，粒徑有減少之趨勢。T1-11微球的乘載率會隨著PLGA濃度提高而上升，最高乘載率為25.1±3.0%。體外釋放試驗結果顯示T1-11自微球中的釋放可分為兩個階段：初期的快速釋放，以及在48小時後的緩慢釋放。體外釋放試驗結果顯示，T1-11自微球至14天的釋放比例約為50%，顯示利用微球包覆技術，可使T1-11達到長效釋放的效果。 A new chemical entity, T1-11, can be extracted from a tradition Chinese medicine, Gastrodia elata. T1-11 is able to slow down the progress of neurodegenerative disease. Since patients with neurodegenerative disease might have movement and cognitive disorders, such as chorea, dysphagia and dementia that cause tablets to be inconvenient for clinical use, a non-oral and sustained release formulation would therefore be needed. Being one of the most important drug delivery systems, microencapsulation is used in pharmaceutical industry. The aim of this study is to encapsulate T1-11 with PLGA by microencapsulation technique and achieve sustained release of T1-11. In this study, different natures of PLGA were used to encapsulate T1-11 by w/o/w method, and various parameters were evaluated. Spherical shape with porous structure of T1-11 microspheres was observed by scanning electron microscope. Mean diameter of all formulations were among 5~45 μm and decreased as the surfactant PVA concentration increased. Loading efficiency was increased with PLGA concentration, and the highest loading efficiency was 25.1±3.0%. In vitro release of T1-11 from the microspheres can be divided into two stages: a faster release in the early stage, and a slower release after 48 hours. The release of T1-11 from the microspheres up to 14 days in vitro was around 50% of the loaded amount, indicating microsphere encapsulation can be used to prolong the release of T1-11.
描述:	碩士指導教授-蔡翠敏委員-陳儀莊委員-林君榮
資料類型:	thesis
顯示於類別:	[生醫材料暨組織工程研究所] 博碩士論文

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