爆炸導致腦損傷動物模式之建立

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題名:	爆炸導致腦損傷動物模式之建立 Establishment of Blast-induced Traumatic Brain Injury Animal Model
作者:	方雅菁 Fang, Ya-Ching
貢獻者:	醫學科學研究所
關鍵詞:	爆炸超壓;爆炸導致創傷性腦損傷;慢性外傷性腦病變;腦衰蛋白調節反應蛋白-2;膠質原纖維酸性蛋白;肝醣合成酶;激酶-3;神經原特異烯醇脢;TAR去氧核糖核酸結合酶-43;Blast overpressure (BOP);Blast-induced traumatic brain injury (bTBI);Chronic Traumatic Encephalopathy (CTE);Collapsin response mediator protein 2 (CRMP2);Glial fibrillary acidic protein (GFAP);Glycogen synthase kinase 3 (GSK-3);Neuron-specific enolase (NSE);TAR-DNA binding protein 43 (TDP-43)
日期:	2013-07-01
上傳時間:	2018-11-12 15:09:56 (UTC+8)
摘要:	於近年的軍事衝突中，爆炸所引發的腦損傷案例（Blast-induced traumatic brain injury , bTBI）日益增加。此傷害會造成腦神經損傷，導致患者身體機能不全，甚至死亡。然而，爆炸造成傷害的機制仍不完全清楚。過去研究指出，爆炸所引起高壓聲波的直接衝擊是造成此類腦外傷的最主要原因（primary blast injuries）。因此，許多研究團隊試著發展出能造成類似爆炸所造成腦外傷的設備。然而，到目前為止，此類設備的研發製造仍未完備。因此，本實驗的目的為發展出一套可以產生穩定衝擊波造成腦外傷的設備，並用其來探討衝擊波造成腦外傷的病理生理機制。本實驗初步研究顯示，使用不同的氣體及不同厚度或層數的阻隔物質會造成不同的衝擊波。基本上，氦氣所造成的衝擊波相對比使用氬氣為高，不論氬氣或氦氣所產生衝擊波的大小與使用阻隔物質的厚度或層數呈正相關。此外，本衝擊波所造成的腦外傷會引起腦外傷特定生物指標（GFAP）的提升，此結果充分顯示，此產生高壓聲波的設備是一個可有效造成腦外傷的設備。接下來實驗中，我們將用此設備來探討高壓聲波所造成的病理生理機制。 Blast-induced traumatic brain injury (bTBI) has become increasingly common in modern military conflicts, and it is a predominant cause of neurotrauma leading to morbidity and mortality. Mechanisms of the injuries are not well understood; however, studies indicated the main cause of the trauma is the primary blast injuries. As a result, many research teams try to develop devices to induce the traumatic brain injuries mimicking that induced by blast overpressure in the battle field. Nevertheless, the establishment of the device is immature. Therefore, we would like to develop a reliable exposure source generating consistent pressures to study the pathophysiology of bTBI. According to our first-hand findings, different gases and different layers or thicknesses of diaphragms result in different shock waves. Basically, the overpressure induced by helium is higher than that induced by argon. No matter the overpressure is generated by helium or argon, there is a positive correlation between the intensities of the waves and the layers or thicknesses of diaphragms. Moreover, the potential biomarker for neurotrauma induced by blast overpressure, glial fibrillary acidic protein (GFAP), is elevated. Thus, we have established a highly efficient device to produce overpressure causing traumatic brain injuries. Therefore, we will use this device to study the pathophysiology of bTBI.
描述:	碩士指導教授-楊良友委員-林靜茹委員-蕭哲志
資料類型:	thesis
顯示於類別:	[醫學科學研究所] 博碩士論文

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