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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/5228


    题名: 十二指腸潰瘍發生及復發相關因子的研究
    Studies in Factors Related to Development and Recurrence of Duodenal Ulcer
    作者: 張君照
    Chun-Chao Chang
    贡献者: 醫學研究所
    关键词: 十二指腸潰瘍
    胃酸
    幽門螺旋桿菌
    過氧化物岐化
    前列腺素E2
    胃上皮化生
    Duodenal Ulcer
    Gastric acid
    Helicobacter pylori
    Superoxide dismutas
    Prostaglandin E2
    Gastric metaplasia
    日期: 1997
    上传时间: 2009-09-11 15:27:02 (UTC+8)
    摘要: 中文摘要

    本研究在探討造成十二指腸潰瘍發生以及復發之相關因子來設計實驗
    。我們利用電子內視鏡進行上消化道檢查，證實是否有十二指腸潰瘍
    的存在。在胃液酸度與十二指腸潰瘍的關係，我們抽取少許胃液，進
    行胃液酸度pH值檢測，利用student's T test檢定後比較潰瘍患者及
    非潰瘍患者之胃液酸度pH值，結果顯示潰瘍患者有較低的胃液酸度
    （P < 0.05）。在幽門螺旋桿菌與十二指腸潰瘍的關係，我們採取少
    許切片做CLO test以及H&E stain來證實幽門螺旋桿菌存在與否。結
    果顯示十二指腸潰瘍患者有較高的幽門螺旋桿菌感染率（P < 0.05）
    。在自由基與十二指腸潰瘍的關係，我們分析急性潰瘍患者與非潰瘍
    受檢者，十二指腸黏膜中Cu/Zn-SOD的含量，結果顯示在潰瘍活動期，
    十二指腸黏膜有較高含量的Cu/Zn-SOD（P < 0.05）。在前列腺素E2
    與十二指腸潰瘍的關係，我們分析急性潰瘍患者與非潰瘍受檢者，胃
    黏膜組織中前列腺素E2的含量，結果顯示十二指腸潰瘍患者與非潰瘍
    受檢者之胃黏膜組織中，前列腺素E2的含量，在統計學上，並無有意
    義的差異 (P > 0.05)。在十二指腸潰瘍復發的因子上，我們討論再
    生黏膜的組織成熟度並研究十二指腸黏膜之胃上皮化生及球部變形與
    潰瘍復發的相關性，結果顯示再生黏膜的組織成熟度愈差者與胃上皮
    化生的程度及球部變形的程度愈嚴重者，有較高的潰瘍復發率。我們
    的結論是十二指腸潰瘍發生的因子是多樣性，包括攻擊因子如胃酸、
    幽門螺旋桿菌及自由基等過多有關，但是防禦因子如前列腺素E2的含
    量在十二指腸潰瘍上似乎不若胃潰瘍來得明確。此外更重要的是在
    十二指腸潰瘍復發的研究上，發現十二指腸再生黏膜的組織成熟度與
    十二指腸球部變形的程度及胃上皮化生的程度確實與十二指腸潰瘍的
    復發有密切的相關性，而根除幽門螺旋桿菌，可能可以減少十二指腸
    球部變形的程度以及胃上皮化生的程度，因而避免潰瘍的一再復發。
    英文摘要
    A study has been conducted by our institute to investigate
    factors related to development and recurrence of duodenal
    ulcer.TV-endoscopy was used in this study to confirm the
    existence of duodenal ulcer ( DU ) . For studying the
    relationship between gastric acidity and duodenal ulcer,
    small amount of gastric juice were aspirated from patients
    with or without duodenal ulcer during endoscopic examination
    to check the intragastric pH using pH meter . The result
    showed that there was significant lower gastric pH in duodenal
    ulcer patients (P < 0.05) as compared with patients without
    duodenal ulcer. For studying the infection rate of H. pylori
    in patients with duodenal ulcer, gastric specimens were taken
    during endoscopy to perform CLO test and H & E staining. The
    infection rate of H. pylori were 89.4％in DU patients and 50.8％
    in non-ulcer patients. The result showed that DU patients have
    a higher infection rate (P < 0.05) as compared with patients
    without duodenal ulcer. Regarding the relationship between
    free radical and DU, we analyzed Cu/Zn-SOD content in duodenal
    mucosa of acute DU patients and non-ulcer patients. The result
    showed a significant higher content of Cu/Zn-SOD in DU patients
    ( P < 0.05). In conjunction to PGE2 and DU, we analyzed the PGE2
    level of gastric mucosa in both acute DU patients and non-ulcer
    patients and the result showed that there was no significant
    difference between patients with and without duodenal ulcer
    ( P > 0.05). For further studying the recurrence of duodenal
    ulcer, we discussed histological maturity of regenerating mucosa
    and studied the correlation among the grade of gastric
    metaplasia, deformity of duodenal bulb and the recurrence of
    DU. The result showed that the less histological maturity of
    regenerating mucosa, the higher the level of gastric metaplasia
    and the more severe the deformity of duodenal bulb the patient
    have, the higher rate of DU recurrence the patient would have.
    In conclusion, there were multiple factors related to
    development and recurrence of DU, they consist of aggressive
    factors such as gastric acid, H. pylori and excessive free
    radicals and protective factors, such as poor maturity of
    regeneration mucosa. However, we found that PGE2 do not play
    an important role in the DU development. Because the
    correlation among histological maturity of regenerating mucosa,
    the grade of gastric metaplasia, severity of deformity of
    duodenal bulb and ulcer recurrence are highly associated. We
    suppose that eradication of H. pylori could reduce the level
    of gastric metaplasia and deformity of duodenal bulb and thus
    prevent the recurrence of DU.
    数据类型: thesis
    显示于类别:[醫學科學研究所] 博碩士論文

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