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    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/51063


    題名: 荔枝種子之成分及抑制黑色素生成之研究
    Chemical Constituents and Melanogenesis-Inhibitory Activities of Litchi chinensis seeds
    作者: 許雅萍
    Hsu, Ya-Ping
    關鍵詞: 荔枝;黑色素;Litchi;melanin
    日期: 2013-07-02
    上傳時間: 2018-10-05 11:24:06 (UTC+8)
    摘要: 荔枝，為無患子科的植物，生存在亞熱帶、中國南部和台灣等地區。荔枝的果皮呈暗紅色，有瘤狀突起，乾且薄；果肉呈白色透明狀，厚而多汁。根據文獻，荔枝籽具有良好的抗氧化活性；而具有抗氧化活性可能也會具有降低色素沉澱的效果。
    將荔枝籽陰乾後，以95%的酒精萃取三次，濃縮後得598.4克。再經過分配萃取得到乙酸乙酯層98.1克、正丁醇層198.5克和水層210.8克。而經由B16-F10黑色素細胞和酪胺酸酶酵素的活性篩選，乙酸乙酯層皆有最好的效果。取乙酸乙酯層進行管柱層析。經過NMR、MS的鑑定後，共得到20個化合物。
    20個化合物為10個phenolic類化合物、2個coumarin類化合物
    、4個fatty acid類化合物、1個flavonoid類化合物及3個其他類化合物。其中化合物LCS8 (3,4-dihydroxybenzoic acid ethyl ester) 在抑制酪胺酸酶酵素有最好的效果。但在黑色素細胞實驗上具有細胞毒殺性。

    Litchi chinensis, belonging to family Sapindaceae, is a king of subtropical fruit tree and famous for long time in Southeast Asia and Taiwan. The fruits of Litchi chinensis are called “ Lychee ” has dry, red pericarp and white edible aril. The seeds extract of lychee may reduce hyperpigmentation effect. In this study, the seeds of lychee was extracted with 95% ethanol and sequentially partitioned with ethyl acetate, n-butanol and water. Therefor, the ethyl acetate fraction with the higher inhibitory activity for tyrosinase and reduced hyperpigmentation for B16-F10 melanoma cells. The fraction was subjected to silica gel column chromatography. Twenty compounds were obtained and isolated. The structures were identified by NMR, MS and literature data. LCS 8 was inhibit tyrosinase and prevent melanin production. But it has cytotoxicity, how to reduce its toxicity with other ingredients will be the future research work.
    描述: 碩士
    委員-呂彥禮
    委員-蕭哲志
    指導教授-李慶國
    資料類型: thesis
    顯示於類別:[生藥學研究所] 博碩士論文

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