| 摘要: | 發生在鼻、咽、喉、口腔、頸部、顱內等部位的惡性腫瘤稱為頭頸部癌，其中癌化組織位於咽喉部的患者在受過氣切手術後，氣管的重建對於恢復以往的生活有很大的幫助，組織和器官的移植可以提供進行全喉切除手術的喉癌患者重建。然而，合適的供體短缺，而且需要終身服用免疫抑制，還有社會經濟和宗教的擔憂。近年來，組織工程的發展已經能產生細胞接種用的三維支架，它可以代替患病的器官，而不需要抑制免疫，使用再生的方法，合成具有非免疫原性和生物相容性的支架，並成功臨床植入。一個可行的和隨時可以使用的生物工程支架，能夠促進新組織的形成，有利於細胞的粘附和增殖，可以成為一個可靠的替代異體移植物。2008年第一次成功人類氣管移植，是使用去細胞的氣管組織，植入幹細胞進行的。之後氣管組織工程已被廣泛研究，但是，常會發生移植物的近端崩潰的問題，因此，在醫療領域中利用組織工程的技術研發結構上加強的氣管支架是有其需要的。本研究的目的為利用3D列印的方法製造氣管再生支架，希望能製作出具有適當強度以及撓性，生物降解時間合適，而且不會阻礙組織再生，甚至有利於組織再生的氣管再生支架。我們以組裝的方式設計並且印製出氣管支架，在撓性以及其他工具(如：縫線) 的配合性比一體成形的氣管支架更具有發展潛力，而且已通過初步的強度測試以及細胞毒性測試。人工氣管是以醫用高分子材料製成的管狀物，作為氣管代替物用以重建氣管，取代因疾病、癌症或意外傷害而切除了的部分氣管或支氣管。人工氣管需要能與周圍的組織癒合或讓組織生長進入，避免局部感染以及管內腔肉芽的形成，人工氣管同時需要能承受來自周圍組織的壓力不致變形。為了能有更為理想的人工氣管，我們未來需要更多的努力與研究。
Head and neck cancer is a malignant tumor in the nose, pharynx, larynx, mouth, neck, brain and other part. In patients with laryngeal cancer after surgery undergone tracheostomy, tracheal reconstruction will be of great help for the restoration of the previous life. Tissue and organ transplantation can provide patients with laryngeal reconstruction conducted total laryngectomy surgery. However, the problem is the shortage of suitable donor, and the need to take lifelong immune suppression drugs, as well as socio-economic and religious concerns. In recent years, the development of tissue engineering has been able to produce a three-dimensional scaffold for cells seeding; it can replace the defected organ, without the need to suppress the immune system. Using regeneration method, the stent synthesized having a non-immunogenic and biocompatible success in clinical implantation. Viable and biological engineering scaffolds can be used at any time, be able to promote the formation of a new organization, help cell adhesion and proliferation, can become a reliable alternative to allograft. The first successful human trachea transplant in 2008 is the use of acellular trachea tissue implantation combined with stem cells. After tracheal tissue engineering has been extensively studied, but often the proximal graft crash occurs, therefore, in the medical field to utilize the technology research and development structure for tissue engineering tracheal stent has its needs. The purpose of this study is the use of 3D printing method for producing regenerated tracheal stents, hoping to produce with adequate strength and a flexible, biodegradable suitable time, and will not impede tissue regeneration, even in favor tracheal regeneration scaffold for tissue regeneration. We print out and assemble a designed tracheal stent, in flexibility as well as other tools (such as: sutures) complexes has more potential for development is more than one piece of tracheal stent, and has passed the initial strength test and cytotoxicity test. Artificial trachea is a tube-like use of medical polymer materials, and as a trachea substitute to rebuild the partial resected trachea or bronchi, due to illness, cancer or accidental injury. Artificial trachea needs to be able to heal or let tissue growth into the surrounding tissue, avoiding the formation of local infection and granulation of the lumen tube. Artificial trachea also needs to be able to withstand the pressure from the surrounding tissue without deformation. In order to have a more ideal artificial trachea, we need more efforts and research in the future. |
