多型性唾液腺瘤之包膜特性與其細胞多寡性之相關性

Taipei Medical University Institutional Repository > 口腔醫學院 > 牙醫學系 > 博碩士論文 > Item 987654321/50717

請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/50717

題名:	多型性唾液腺瘤之包膜特性與其細胞多寡性之相關性 The relationship between the capsular characteristics of pleomorphic adenoma and its cellularity
作者:	賴俊成 Lai, Chun-Cheng
關鍵詞:	多型性腺瘤;細胞多寡性;包膜特徵;pleomorphic adnoma;cellularity;capsular characteristics
日期:	2016-06-06
上傳時間:	2018-10-03 10:30:11 (UTC+8)
摘要:	多型性腺瘤為最常見的良性唾液腺腫瘤，大約佔所有腮腺腫瘤中的 53%~77%，臨床表現主要為無痛增大。微觀下呈現表皮細胞與漿質兩個部分，並且在漿液性、軟骨性或混合性的漿質中，可看到管腔細胞與肌上皮細胞組成片狀、微囊腫狀、島狀或是絲狀的腫瘤細胞團塊。它的復發性大約介於0% ~17%之間。根據研究其復發性與包膜特徵有關，本篇研究利用細胞多寡性評估腫瘤細胞的侵襲性，並且試圖找到細胞多寡性與包膜特徵的相關性。本研究的患者檢體，以台北醫學大學附設醫院病理科病例查詢系統資料庫，收集從2008年5月至2015年4月的病例。這些病例中的手術形式為切除術、淺層腮腺切除術或全腮腺切除術。所蒐集到的89個病例中，2例為惡性腫瘤，22例資料不夠完整，最後得到臨床資料完整的病例數目為65例。在剩餘的65個病例當中，其中2例因為細胞多寡性難以判讀而3例因為標本碎裂成多塊而排除，於是剩下60例。此60例中，去除因為病理切片不完整的11例，最後得到能夠分析包膜特徵與細胞多寡性關係的病例數為49例。在分析完包膜特徵與細胞多寡性關係的49個病例後，我們得知腫瘤存在的時間越長細胞多寡性越低。手術邊緣乾淨與否與衛星結節的產生和細胞密度之間沒有相關性，只有包膜的完整與否和多型性腺瘤的細胞密度有關。 Pleomorphic adenoma is a common benign tumor of the salivary glands seen in daily clinical practices, composed of epithelial and stroma elements with 53%~77% prevalence for parotid tumors. The ductal and myoepithelial cells are organized into sheet, cyst-like, island or cord patterns within the myxoid, chondroid, or mixed stroma. A major clinical manifestation is neglected painless swelling with recurrence rate of 0~17%. Because of its relatively high recurrence rate, this study evaluated the relationships between the capsular characteristics and the cellularity of the pleomorphic adenoma. Cases were collected from May 2008 to April 2015 in the database of the Pathological Department of Taipei Medical University Hospital. All specimens were excision, superficial parotidectomy or total parotidectomy. Of 89 patients, 24 were excluded due to 2 malignant transformation , and 22 due to inadequate data. Of 65 cases, we retrospectively reviewed clinical data and excluded 2 cases and another 3 specimens because of difficulty in evaluating the cellularity and broken to several pieces respectively. Of 60 patients, 11 were ruled out due to incompleteness of pathological sections. Finally, 49 cases were reserved to analyze the relations between the capsular characteristics and the cellularity of the pleomorphic adenoma. Results revealed that the longer the tumor has existed in the body, the lower the cellularity is and then there is no relationship between the cellularity and the positive resection margin or presence of satellite nodules. However, integrity of the capsule is related with the cellularity of the pleomorphic adenoma.
描述:	碩士指導教授-林哲堂委員-林永和委員-林弘斌
資料類型:	thesis
顯示於類別:	[牙醫學系] 博碩士論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	224	檢視/開啟

檢視Licence

在TMUIR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....