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    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/50525


    題名: 新型磷酸鈣骨替代物應用於齒槽骨嵴保存術之探討
    Study of New Calcium Phosphate Bone Substitutes in Alveolar Bone Preservation
    作者: 石采芹
    CHIN, SHIH TSAT
    關鍵詞: 磷酸鈣鹽類;硫酸鈣;生物相容性;小獵犬;Hydroxyapatite?z calcium sulfate?z biocompatibility?z beagle?
    日期: 2012-07-27
    上傳時間: 2018-10-02 09:47:08 (UTC+8)
    摘要: 磷酸鈣鹽類(Ca10(PO4)6(OH)2)，具有高度生物相容性，好的生物親和性又可引導骨生長並且在植入生物體後又可慢慢被宿主細胞代謝的優點，但其在於臨床上的應用還是有需要改善的部分，尤其是在生物體內有體液情況更是會隨著體液懸浮難以塑型。
    硫酸鈣(Calcium sulfate) 是一種在生物體內快速吸收並且釋放鈣離子的骨替代物，但是卻無法提供穩定長期三D立體的支架結構，故無法有骨引導功能。同時其加水混和後並不會固化而是成糊狀，故若妥善應用有時可增加手術操作的便利性。
    本實驗主要是觀察生物體內磷酸鈣鹽類(Ca10(PO4)6(OH)2)/ 硫酸鈣(Calcium sulfate)混和物，意即(Hydroxyapatite, apatitic phase) / calcium sulfate dehydrate (CSD) composite以不同的比例30/70、 50/50及70/30分別放入英國小獵犬下顎齒槽骨的小臼齒拔牙後窩槽 ，控制組維持空的什麼都沒放，觀察五週及十週，分別比較齒槽骨寬度及高度變化、組織型態觀察及分析，Hydroxyapatite, apatitic phase) / calcium sulfate dehydrate (CSD) composite比例30/70 在本研究中比較符合臨床需求。

    Hydroxyapatite (Ca10(PO4)6(OH)2), with its high biocompatibility and good bioaffinity, stimulates osteoconduction and is slowly replaced by the host bone after implantation. However, clinical use of HA as a bone substitute has proven problematic. It is difficult to prevent dispersion of the HA granules and to mold the granules into the desired shape.
    Calcium sulfate as a bone graft substitute is rapidly resorbed in vivo releasing calcium ions, but fails to provide a long-term, three-dimensional framework to support osteoconduction. The setting properties of calcium sulfate, however, allow it to be applied in a slurry form, making it easier to handle and apply in different situations.
    This study examines the in vivo response of a (Hydroxyapatite, apatitic phase) / calcium sulfate dehydrate (CSD) composite using different ratios in the mandibular premolar sockets of the beagle. The HA (AP) / CSD composite materials prepared in ratios of 30/70, 50/50, and 70/30 were implanted into the mandibular premolar sockets for five and ten weeks. The control socket was empty. We compared the histology and the changes in height and width of the mandibular premolar sockets in the beagle. The composite graft in the 30/70 ratio had the best ability to form new bones.
    描述: 博士
    指導教授-林哲堂
    委員-黃豪銘
    委員-蘇正堯
    委員-蘇慶華
    委員-劉巡宇
    委員-鄭暻暉
    共同指導教授-張維仁
    資料類型: thesis
    顯示於類別:[牙醫學系] 博碩士論文

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