體脂肪、內臟脂肪與非酒精性脂肪肝病之關係

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Title:	體脂肪、內臟脂肪與非酒精性脂肪肝病之關係 The correlation between body fat, visceral fat and nonalcoholic fatty liver disease
Authors:	柯蘊慧 Ko, Wei-Huei
Contributors:	公共衛生學系暨研究所楊淑惠
Keywords:	內臟脂肪,體脂肪,非酒精性脂肪肝病,生物電阻法 visceral fat,body fat,nonalcoholic fatty liver,bioelectrical impedance analysis
Date:	2016-06-24
Issue Date:	2018-10-01 11:35:31 (UTC+8)
Abstract:	本研究目的為探討體脂肪、內臟脂肪與非酒精性脂肪肝病（non-alcohol fatty liver disease, NAFLD）之關係。試驗為橫斷面、回溯性研究，從台北市立聯合醫院仁愛院區醫院健檢中心資料庫中回溯收集2013年10月至2015年9月間的健康檢查資料，研究對象為健康檢查年齡大於20歲的受檢者，排除病毒性脂肪肝病、酒精性脂肪肝病、肝硬化、肝癌、膽道系統疾病、服用治療糖尿病或高血壓藥物者。以病歷回顧方式收集受試者基本資料、體位測量值、血液生化數值及以生物電阻法儀器（InBody 720, Biospace, Seoul, Korea）測量得之體組成體脂肪與內臟脂肪數值、以超音波檢測脂肪肝嚴重程度的診斷結果。試驗以SPSS21.0版進行統計分析，當p < 0.05具顯著意義。研究結果顯示，共計2,759位完成資料分析，單變項分析NAFLD的罹病率發現男性高於女性。以多變項邏輯式迴歸分析NAFLD的顯著危險因子包括：身體質量指數過高、腰圍過高、體脂肪率過高、內臟脂肪過高、有代謝症候群者。以ROC分析發現內臟脂肪相較於體脂肪是預測NAFLD更好的指標，同時建議內臟脂肪之切點為70.5cm²（Youden's index=0.4352）。結論：內臟脂肪可以為NAFLD很強的危險預測因子。 Objective: The aim of this study is to investigate the correlation between body fat, visceral fat and presence of nonalcoholic fatty liver disease(NAFLD). Design: It is a cross-sectional study. Subjects: We collected data from physical examination subjects at Renai Branch of Taipei City Hospital from October 2013 to September 2015. The enrolled criteria required participants be 20 years or older. All subjects those with liver disease(hepatitis C virus antibody or hepatitis B surface antigen)or cirrhosis or malignant disease or biliary disease or use of antihypertensive or antidiabetic agents were excluded. Methods: Demographic data, biochemical data, body fat, visceral fat, fatty liver were collected by chart review. Body fat and visceral fat assessed by InBody 720 (Biospace, Seoul, Korea). Fatty liver was diagnosed by abdominal ultrasound. SPSS software version 21.0 was used to perform statistical analyses. A p value less than .05 was considered as statistic significance. Results: A total of 2,759 subjects were collected this study. The result of the analysis revealed that in terms of prevalence of NAFLD males exhibited a higher incidence than females. Those factors such as waist circumference, body mass index, body fat, visceral fat and metabolic syndrome were correlation with NAFLD. Multiple logistic regression was used in further analysis, showing that increased waist circumference, body mass index, body fat, visceral fat and metabolic syndrome were significant correlated factors for the present of fatty liver. Receiver operating characteristic suggested that visceral fat cut off point was 70.5 cm²(Youden's index=0.4352). Conclusion: Visceral fat was a strong predictor of NAFLD.
Description:	碩士論文指導教授-楊淑惠委員-劉珍芳委員-韓柏檉
Data Type:	thesis
Appears in Collections:	[School of Public Health] Thesis

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