Increased risk of adverse pregnancy outcomes in women with Rheumatoid Arthritis: a nationwide population-based study

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TMUIR > College of Medicine > Department of Medicine > Department of Pediatrics > Original Paper > Item 987654321/44730

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Title:	Increased risk of adverse pregnancy outcomes in women with Rheumatoid Arthritis: a nationwide population-based study
Authors:	Lin,Herng-Ching;Chen,Shu-Fen;林秀真;Chen,Yi-Hua
Contributors:	台北醫學大學附設醫院小兒學科
Keywords:	rheumatoid arthritis;pregnancy outcome;low birthweight
Date:	2009-04-29
Issue Date:	2012-01-30 16:34:52 (UTC+8)
Abstract:	Objective: Using a three-year nationwide population-based database (2001-2003), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes, after adjusting for characteristics of infant, mother and father. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1,912 mothers with RA and 9,560 matched comparison mothers were included for analysis. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia, and delivery mode (vaginal vs. cesarean section (CS)) for the study and comparison groups, after adjusting for potential confounders. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia, and CS for women with RA were 1.47 (95% CI=1.22-1.78), 1.20 (95% CI=1.05-1.38), 2.22 (95% CI=1.59-3.11), and 1.19 (95% CI=1.07-1.31) times, respectively, that of comparison mothers. Conclusion: After adjusting for potential confounding factors, women with RA had increased risk of LBW, SGA babies, preeclampsia, and CS, compared with unaffected women. Our findings suggest a need for active monitoring and early intervention to counter the increased risk of adverse obstetric outcomes for pregnant women with RA.
Relation:	Annals of the rheumatic diseases. 69(4): 715-717.
Appears in Collections:	[Department of Pediatrics] Original Paper

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