Taipei Medical University Institutional Repository:Item 987654321/44711
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    Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/44711


    Title: Allelic Diversity of zmpB Contributes to Complicated Pneumonia Caused by Streptococcus pneumoniae
    Authors: Yu-Chia Hsieh;Po-Nien Tsao;Chi-Long Chen;Wen-Sen Lee;Pei-Lan Shao;Chin-Yun Lee;Po-Ren Hsueh;Li-Min Huang;Jin-Town Wang
    Date: 2011
    Issue Date: 2012-01-19 09:49:44 (UTC+8)
    Abstract: Complicated pneumonia, including necrotizing pneumonia, lung abscess, and empyema ，臼used by Streptococcus pneumoniae has been increasing.
    To study its virulence in an animal model and identify virulence factors of S. pneumoniae associated w ith this emerging infectious disease. We used
    a young mouse inoculation model to monitor bacterial virulence and a microarray to compare gene expression between S. pneumoniae from children
    with ∞mpli臼ted and non-∞mpli開始d pneumonia. We established a novel model of complicated pneumonia in young mice infected with strains of
    the m司or pulse-field gel electrophoresis (PFGE) type of serotype 14 of S. pneumoniae found in children with complicated pneumonia (NTUH-p28
    and NTUH-p15, ST46). In a microarray analys 惱， differences in zmpB RNA hybridization between NTUH-p28 and a strain, NTUH-p3 (ST328), from a
    child with pneumococcal lobar pneumonia, were found. Confirmatory assays revealed sequence variation in the zmpB gene between the two strains
    (NTUH-p28 and NTUH-p15) from complicated pneumonia and that from non-complicated pneumonia (NTUH-p3). Infection with the 6 zmpB mutant
    of NTUH-p15 showed a significant decrease in the severity of pneumonia and no destructive lung injury. The zmpB ∞mplementation strain of NTUHp15
    significantly restored the level of inflammation and 臼used lung neαosis . Complemen個tion of the 6 zmpB mutant of NTUH-p3 with zmpB of
    NTUH-p15 resulted in a higher bacterial burden than that in wild type NTUH-p3. In conclusion, allelic diversity of zmpB a仟ects the virulence of S.
    pneumoniae. zmpB of NTUH-p15 is an important virulence factor in S. pneumoniae causing complicated pneumonia in children.
    Appears in Collections:[Department of Internal Medicine] Periodical Articles

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