Taipei Medical University Institutional Repository:Item 987654321/4465
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 45073/58249 (77%)
造訪人次 : 2387758      線上人數 : 157
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/4465


    題名: 米麩油及其成分γ- oryzanol 對第 2 型糖尿病大鼠胰島素抗性及脂質代謝的影響
    The effects of rice bran oil and γ- oryzanol on insulin resistance and lipid metabolism in rats with type 2 diabetes mellitus
    作者: 馬千雅
    Chien Ya-Ma
    貢獻者: 保健營養學研究所
    日期: 2007
    上傳時間: 2009-09-08 12:16:57 (UTC+8)
    摘要: 本次研究目的欲探討米麩油及其成分γ - oryzanol對於第2型糖尿病大鼠胰島素抗性及脂質代謝之影響。實驗採用32隻wistar品系雄性大鼠，經由streptozotozin（STZ）誘導成第2型糖尿病模式。實驗為期5週，飲食以AIN93-M為基礎，油脂由4%修改為15%之高油飲食。實驗分為四組:控制組（C）、米麩油組（RBO），棕櫚油組（PO）及棕櫚油添加γ- oryzanol組（POO）。油脂分別使用大豆油、米麩油或棕櫚油。於第零週及第五週以腹腔注射葡萄糖耐受試驗評估胰島素敏感性，且於第五週採集實驗動物糞便。5週後犧牲，分析項目包括：禁食血漿葡萄糖、胰島素、三酸甘油酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇、脂肪酸組成、葡萄糖及胰島素濃度曲線下面積；肝臟三酸甘油酯、總膽固醇、脂肪酸組成；糞便中性固醇及膽酸排出量。結果顯示，四週實驗後，RBO組及POO組可改善胰島素抗性。在血脂的部份，RBO組及POO組皆顯著降低低密度脂蛋白膽固醇濃度、增加高密度脂蛋白膽固醇濃度、降低總膽固醇/高密度脂蛋白膽固醇比值、降低三酸甘油酯濃度、降低游離脂肪酸濃度。肝臟脂質的部份，RBO組及POO組顯著降低肝臟中三酸甘油酯及膽固醇含量。糞便中性固醇及膽固醇排出量的部份，RBO組及POO組能增加其排出量。上述結果得知，米麩油及其成分γ - oryzanol具有改善第2型糖尿病大鼠胰島素抗性及脂質代謝。
    BACKGROUND AND METHODS: The prevalence of type 2 diabetes mellitus (T2DM) has dramatically increased in the last few years. Cardiovascular disease (CVD) is a major cause of mortality in patients with diabetes, and dyslipidemia is a major CVD risk factor. Rice bran oil is rich in γ- oryzanol, a compound from the unsaponifiable fraction, and has antioxidant and hypolipidemia properties. Palm oil accounts for 18.6% of the total world vegetable oil production, and is next only to soybean oil in terms of world production. The potential of palm oil to cause hyperlipidemia has been proposed, because it is low in polyunsaturated fat and high in saturated fat, predominantly palmitic acid. The aim of this study was to investigate the effects of rice bran oil and γ -oryzanol on insulin resistance and lipids metabolism in T2DM rats. Rats with streptozotocin/nicotinamide-induced T2DM were divided into control (soybean oil), RBO (rice bran oil), PO (palm oil), POO (palm oil plus γ- oryzanol) groups fed cholesterol-free diets containing 15 g of oil per 100 g diet. RESULT: Of the four groups, the PO group had the highest plasma triglycerides concentration. The LDL-C concentration was higher in the PO group than the control and RBO groups. HDL-C concentration was higher in the RBO and POO groups than PO group. The TC/HDL-C ratio was lower in the RBO and POO groups than the control and PO groups. Hepatic total cholesterol concentration was lower in the RBO group than the control and PO groups, and hepatic triglycerides concentration was higher in the PO group than others group. Fecal neutral sterol and bile acid concentration was higher in the RBO and POO groups than control and PO groups.
    CONCLUSION: The rice bran oil diet significantly improved insulin resistance and lipid metabolism in rats with type 2 diabetes mellitus. γ- Oryzanol has a lipid lowering effect and can therefore improve hyperlipidemia due to ingestion of palm oil.
    資料類型: thesis
    顯示於類別:[保健營養學系暨研究所] 博碩士論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    摘要.doc29KbMicrosoft Word69檢視/開啟
    摘要.pdf152KbAdobe PDF107檢視/開啟
    摘要.ppt142KbMicrosoft Powerpoint176檢視/開啟


    在TMUIR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    著作權聲明 Copyright Notice

    • 本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。

      The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.

    • 瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。

      By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.

    • 本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。

      TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

    Back to Top
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋