Baseline serum matrix metalloproteinase-9 level predicts long-term prognosis after coronary revascularizations in stable coronary artery disease.

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Taipei Medical University Institutional Repository > 臺北醫學大學 • 萬芳醫院 > 心臟內科 > 期刊論文 > Item 987654321/44189

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題名:	Baseline serum matrix metalloproteinase-9 level predicts long-term prognosis after coronary revascularizations in stable coronary artery disease.
作者:	Ye ZX;Leu HB;Wu TC;Lin SJ;Chen JW.
日期:	2007
上傳時間:	2011-08-10 14:18:10 (UTC+8)
摘要:	OBJECTIVES: This study aimed to investigate whether baseline serum levels of matrix metalloproteinases (MMPs) could predict long-term prognosis of coronary revascularizations. DESIGNS AND METHODS: Ninety-one consecutive patients receiving coronary revascularizations (58 percutaneous coronary interventions and 33 coronary artery bypass graft surgeries) for stable coronary artery disease (CAD) were studied. Baseline serum levels of high-sensitive C-reactive protein (hsCRP), MMP-2, -3 and -9 drawn before revascularization were correlated to the clinical adverse events within >12 months after revascularizations. RESULTS: Baseline characteristics were similar between the two groups. There were total 22 major adverse cardiovascular events during a mean period of 27 months. Only baseline serum MMP-9 level independently predicted future cardiovascular events after coronary revascularization either by multivariate analysis (relative risk 3.18, p=0.028) or by Kaplan-Meier analysis (p=0.021). CONCLUSIONS: Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable CAD
關聯:	Clin Biochem. 2008 Mar;41(4-5):292-8. Epub 2007 Nov 21.
顯示於類別:	[心臟內科] 期刊論文

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