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    題名: Metoclopramide-induced supersensitivity psychosis.
    作者: 盧孟良
    貢獻者: 醫學系精神學科
    日期: 2002
    上傳時間: 2011-03-29 11:40:27 (UTC+8)
    摘要: OBJECTIVE: To report 2 cases of metoclopramide-induced supersensitivity psychosis.

    CASE SUMMARIES: A 74-year-old Taiwanese man was treated with metoclopramide 5 mg 4 times daily for 6 months. A second patient, a 65-year-old Taiwanese man, was treated with metoclopramide 5 mg 4 times daily for 3 months. After discontinuation of metoclopramide, both patients developed hallucinatory experiences and delusions.

    DISCUSSION: This is the first report of metoclopramide-induced supersensitivity psychosis. Chronic administration of a dopamine antagonist (e.g., metoclopramide) might induce dopamine receptor supersensitivity. It is hypothesized that exacerbation or occurrence of psychotic symptoms following neuroleptic withdrawal results from mesolimbic dopamine supersensitivity.

    CONCLUSIONS: The complications of long-term metoclopramide therapy should be seriously considered when the treatment regimens are being planned. Clinicians should attempt to treat patients with the lowest effective dosage of medication for the briefest therapeutic period to minimize the risks of adverse reactions.
    關聯: The Annals of Pharmacotherapy. 36: 1387-1390.
    顯示於類別:[精神學科] 期刊論文

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