Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia

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TMUIR > College of Medicine > Department of Medicine > Department of Anesthesiology > Periodical Article > Item 987654321/4009

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/4009

Title:	Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia
Authors:	溫永銳 Wen YR;Suter MR;Ji RR;Wu YS;Kohno T;Wang KC;Sun WZ;Wang CC
Contributors:	醫學系麻醉學科
Date:	2008
Issue Date:	2009-08-25 15:33:27 (UTC+8)
Abstract:	BACKGROUND: Recent studies have implicated the activation of stress-activated mitogen-activated protein kinase (MAPK) p38 in spinal microglial cells for development of neuropathic and inflammatory pain. The aim of the present study was to investigate whether phosphorylation of p38 (p-p38) also mediates mechanical allodynia and thermal hyperalgesia induced by plantar incision. METHODS: After rats received a plantar incision surgery, mechanical allodynia and thermal hyperalgesia were determined by von Frey filaments and radiant heat, respectively, and the number of p-p38 immunoreactive cells in the dorsal horn was quantified to determine p38 activation at different time points after incision. The p38 inhibitor FR167653 was administered intrathecally 30 min before hind paw plantar incision to determine the role of p38 in postoperative pain. RESULTS: A significant increase in number of p-p38 immunoreactive cells was observed in the ipsilateral L4-5 spinal dorsal horn from 1 h to 3 days after the incision. p-p38 was found predominantly in microglia. However, microglial activation (assessed by OX-42 upregulation) was not evident until 3 days after plantar incision. Intrathecal pretreatment of FR167653 attenuated incision-induced mechanical allodynia from 1 h to day 2 and significantly reduced activation of p38 in the dorsal horn 1 day after plantar incision. However, FR167653 only inhibited heat hyperalgesia at an early time point. CONCLUSIONS: Plantar incision-induced mechanical allodynia can be prevented by the p38 inhibitor. Our results suggest that p38 activation in spinal microglia play a role in incision-induced mechanical allodynia in rats. Therefore, p38 inhibition may be useful in treating postsurgical pain.
Relation:	Anesthesiology.(110):55-65.
Data Type:	article
Appears in Collections:	[Department of Anesthesiology] Periodical Article

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