Hyperinsulinaemia associated with beta-adrenoceptor antagonist in medicated bipolar patients during manic episode.

English | 正體中文 | 简体中文 | 全文筆數/總筆數 : 45346/58522 (77%)
造訪人次 : 2505070 線上人數 : 249

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Taipei Medical University Institutional Repository > 醫學院 > 醫學系 > 精神學科 > 期刊論文 > Item 987654321/3948

請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/3948

題名:	Hyperinsulinaemia associated with beta-adrenoceptor antagonist in medicated bipolar patients during manic episode.
作者:	李信謙 Tsai SY;Lee HC;Chen CC
貢獻者:	醫學系精神學科
日期:	2007
上傳時間:	2009-08-25 14:47:18 (UTC+8)
摘要:	Hyperinsulinaemia, a pre-clinical condition which is considered to predict insulin resistance and metabolic syndrome, has not been sufficiently investigated in bipolar disorder, despite evidence to suggest that bipolar patients are at risk of developing insulin resistance. This study was set out to determine the alteration in fasting insulin levels and evaluate the factors associated with hyperinsulinaemia during manic episodes. Measurements were taken of the fasting plasma insulin and leptin levels, as well as the body mass index (BMI), amongst 42 physically healthy bipolar I manic (DSM-IV) patients aged ≤ 45 with Young Mania Rating Scale (YMRS) scores of ≥ 26. These were then compared with their values in subsequent remission (YMRS ≤ 12). A total of 14 patients (33.3%) in acute mania and 30 patients (71.4%) in subsequent remission met the Taiwanese criteria for hyperinsulinaemia of ≥ 8.7 μIU/ml for men, and ≥ 11.3 μIU/ml for women. Multiple analyses were then undertaken, without correction, as the exploratory analyses. The measurement, by logistic regression, of the use of propranolol in remission (odds ratio [OR] = 10.04, 95% confidence interval [95% CI] = 1.03–97.96) and the increase in BMI (OR = 1.35, 95% CI = 1.01–1.80) were found to have independent associations with hyperinsulinaemia in subsequent remission. Our results suggest that medicated bipolar manic patients are vulnerable to hyperinsulinaemia in early remission, particularly those gaining bodyweight or those using β-adrenoceptor antagonist (beta-blockers), irrespective of the types of mood stabilizers or antipsychotics used. Keywords: Beta-blocker; Bipolar I disorder in Taiwan; Bodyweight gain; Hyperinsulinaemia; Insulin resistance; Manic episode
關聯:	Prog Neuropsychopharmacol Biol Psychiatry.
資料類型:	article
顯示於類別:	[精神學科] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
H-123.pdf	163Kb	Adobe PDF	96	檢視/開啟
全文.txt	0Kb	Text	221	檢視/開啟
摘要.pdf	48Kb	Adobe PDF	81	檢視/開啟

在TMUIR中所有的資料項目都受到原著作權保護.

TAIR相關文章

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

資料載入中.....