ASK1 in Amyloid β Peptide-Induced Cerebral Endothelial Cell Apoptosis

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題名:	ASK1 in Amyloid β Peptide-Induced Cerebral Endothelial Cell Apoptosis
作者:	許銘仁 Hsu MJ;Hsu CY;Chen BC;Chen MJ;Ou Geprge;Lin CH
貢獻者:	醫學系藥理學科
日期:	2007
上傳時間:	2009-08-25 14:13:56 (UTC+8)
摘要:	A pathological hallmark of Alzheimer's disease is accumulation of amyloid-beta peptide (Abeta) in senile plaques. Abeta has also been implicated in vascular degeneration in cerebral amyloid angiopathy because of its cytotoxic effects on non-neuronal cells, including cerebral endothelial cells (CECs). We explore the role of apoptosis signal-regulating kinase 1 (ASK1) in Abeta-induced death in primary cultures of murine CECs. Abeta induced ASK1 dephosphorylation, which could be prevented by selective inhibition of protein phosphatase 2A (PP2A) but not PP2B. ASK1 dephosphorylation resulted in its dissociation from 14-3-3. ASK1, released from 14-3-3 inhibition, activated p38 mitogen-activated protein kinase (p38MAPK), leading to p53 phosphorylation. p53, a proapoptotic transcription factor, in turn transactivated the expression of Bax, a proapoptotic protein. Transfection with various dominant-negative mutants (DNs), including ASK1 DN and p38MAPK DN, suppressed Abeta-induced p38MAPK activation, p53 phosphorylation, and Bax upregulation and partially prevented CEC death. Bax knockdown using a bax small interfering RNA strategy also reduced Bax expression and subsequent CEC death. These results suggest that Abeta activates the ASK1-p38MAPK-p53-Bax cascade to cause CEC death in a PP2A-dependent manner
關聯:	J. Neurosci
資料類型:	article
顯示於類別:	[藥理學科] 期刊論文

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