Taipei Medical University Institutional Repository:Item 987654321/3789
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    题名: Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells.
    作者: 李宏謨
    Jan HJ;Lee CC;Lin YM;Lai JH;Wei HW;Lee HM
    贡献者: 醫學檢驗暨生物技術學系
    关键词: Matrix metalloproteinase;Glioma;Mitogen activated protein kinase phosphatase-1
    日期: 2008
    上传时间: 2009-08-25 10:38:59 (UTC+8)
    摘要: We sought to investigate the molecular mechanisms by which rosiglitazone (RGZ) inhibits
    cell invasion in human glioma cells. In this study, we found that RGZ attenuated MMP-2
    protein levels, MMP-2 gelatinolytic activity, and cell invasiveness through a PPAR-c independent
    pathway. RGZ increased mitogen activated protein kinase phosphatase-1 (MKP-1)
    expression. The addition of triptolide (a diterpenoid triepoxide, which blocked MKP-1
    induction) abolished the inhibitory effects by RGZ. Furthermore, we demonstrated that
    the knock down of MKP-1 by MKP-1 specific small interference RNA reversed the reduction
    of MMP-2 secretion, and of cell invasiveness by RGZ. In contrast, the stable expression of
    MKP-1 in glioma cell lines decreased MMP-2 activity and cell invasiveness. These results
    suggest that RGZ may mediate the inhibitory effects through MKP-1 induction. Thus,
    MKP-1 could be a potential target in glioma therapy.
    關聯: Cancer lett.(In pre):1-1.
    数据类型: article
    显示于类别:[醫學檢驗暨生物技術學系所] 期刊論文

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