Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid.

English | 正體中文 | 简体中文 | 全文筆數/總筆數 : 45422/58598 (78%)
造訪人次 : 2514671 線上人數 : 145

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Taipei Medical University Institutional Repository > 醫學科技學院 > 醫學檢驗暨生物技術學系所 > 期刊論文 > Item 987654321/3785

請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/3785

題名:	Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid.
作者:	何元順 Tain-Junn Cheng;Ying-Jan Wang;Wei-Wan Kao;Rong-Jane Chen;Yuan-Soon Ho
貢獻者:	醫學檢驗暨生物技術學系
關鍵詞:	Lipoic acid;Arsenic trioxide;Neurotoxicity;Autophage
日期:	2007
上傳時間:	2009-08-25 10:38:55 (UTC+8)
摘要:	Arsenic is an environmental toxicant found naturally in ground water. Epidemiological studies have suggested a correlation between chronic arsenic exposure and potential brain tissue damage in clinical case and animal experiments. Lipoic acid (LA) is a thiol-compound naturally occurring in plants and animals, which is thought to be a strong antioxidant and possess neuroprotective effects. The objective of this study was to determine if the AS2O3-induced glial cell toxicity could be prevented by LA. The human malignant glioma cell (U118) was selected as a research model. By using acridine orange staining and flow cytometry analysis, we found that autophagic, but not apoptotic, cell death was significantly induced by AS2O3 in U118 cells, and that AS2O3-mediated autophagic cell death was nearly completely attenuated by LA. Down-regulation of p53 and Bax proteins and the up-regulation of Bcl-2 and HSP-70 proteins were observed by western blot in AS2O3-mediated autophagic cell death. Our results implied that LA completely inhibited U118 cells autophagic cell death induced by AS2O3. We suggested that LA may emerge as a useful protective agent against arsenic-induced glial cell toxicity and reversing arsenic-induced damage in human brain.
關聯:	Food and Chemical Toxicology.(45):1027-1038.
資料類型:	article
顯示於類別:	[醫學檢驗暨生物技術學系所] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
168.pdf	1334Kb	Adobe PDF	200	檢視/開啟
全文.txt	0Kb	Text	275	檢視/開啟
摘要.pdf	34Kb	Adobe PDF	81	檢視/開啟

在TMUIR中所有的資料項目都受到原著作權保護.

TAIR相關文章

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

資料載入中.....