Taipei Medical University Institutional Repository:Item 987654321/3771
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    题名: Magnolol inhibits human glioblastoma cell oroliferation through upregulation of p21/Cip1
    作者: 何元順
    Li-Ching Chen;Yu-Chi Liu;Yu-Chih Liang;Yuan-Soon Ho;Wen-Sen Lee
    贡献者: 醫學檢驗暨生物技術學系
    日期: 2009
    上传时间: 2009-08-25 10:38:39 (UTC+8)
    摘要: Previously, we demonstrated that magnolol isolated from the bark of Magnolia officinalis has anticancer activity in colon, hepatoma, and leukemia cell lines. In this study, we show that magnolol concentration dependently (0-40 muM) decreased the cell number in a cultured human glioblastoma cancer cell line (U373) and arrested the cells at the G0/G1 phase of the cell cycle. Magnolol treatment decreased the protein levels of cyclins A and D1 and increased p21/Cip1, but not cyclins B and D3, cyclin-dependent kinase (CDK)2, CDK4, CDC25C, Weel, p27/Kip1, and p53. The CDK2-p21/Cip1 complex was increased, and the CDK2 kinase activity was decreased in the magnolol-treated U373. Pretreatment of U373 with p21/Cip1 specific antisense oligodeoxynucleotide prevented the magnolol-induced increase of p21/Cip1 protein levels and the decrease of DNA synthesis. Magnolol at a concentration of 100 muM induced DNA fragmentation in U373. Our findings suggest the potential applications of magnolol in the treatment of human brain cancers.
    關聯: Journal of Agriculture Food Chemistry.
    数据类型: article
    显示于类别:[醫學檢驗暨生物技術學系所] 期刊論文

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