Taipei Medical University Institutional Repository:Item 987654321/3757
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    题名: Human Papillomavirus Genotyping for the Eight Oncogenic Types Can Improve Specificity of HPV Testing in Women with Mildly Abnormal Pap Results
    作者: 林景堉
    Guo Ming;Lin CY;Gong Yun;Cogd David E;Zhang Wei;Lin E;Sneige Nour
    贡献者: 醫學檢驗暨生物技術學系
    关键词: Papillomavirus;Human;Human Females;DNA;Cervical intraepithelial neoplasia grade 2;R36
    日期: 2008
    上传时间: 2009-08-25 10:38:23 (UTC+8)
    摘要: To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can
    improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with
    mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16,
    18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US,
    94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in
    90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly
    associated with CIN 2/3/carcinoma (Po0.001) in women with ASC-US, but not in women with LSIL (P¼0.52). Of
    HPV DNA-positive specimens, the eight oncogenic HPV types were detected in 83% of HSIL cases (15/18), 53%
    of LSIL cases (21/40), and 47% of ASC-US cases (28/60). The eight oncogenic HPV types were significantly
    associated with CIN 2/3/carcinoma (OR, 10.6; 95% CI, 3.98–28.10; Po0.001), whereas no significant association
    was observed between the non-eight oncogenic HPV types and CIN 2/3/carcinoma (OR, 2.20; 95%CI, 0.80–6.03;
    P¼0.125). In women with ASC-US, HPV genotyping for the eight oncogenic types showed higher specificity (81
    vs 46%) and positive predictive value (PPV, 44 vs 26%) in predicting CIN 2/3/carcinoma compared to HPV DNA
    testing. Similarly, in women with LSIL, higher specificity (69 vs 8%) and PPV (62 vs 39%) for predicting CIN
    2/3/carcinoma were also observed using HPV genotyping test for the eight oncogenic types compared to HPV
    DNA testing. Our findings suggested that HPV genotyping for the eight oncogenic types might be useful to
    improve the efficacy of HPV DNA testing for predicting CIN 2/3/carcinoma in women with mildly abnormal Pap
    results, which may lead to personalized clinical management with improved patient compliance for follow-up.
    關聯: Modern Pathology.(21):1037-1043.
    数据类型: article
    显示于类别:[ ] Periodical Articles

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