The molecular events occur during MK-801-induced cytochrome oxidase subunit II down-regulation in GT1-7 cells.

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題名:	The molecular events occur during MK-801-induced cytochrome oxidase subunit II down-regulation in GT1-7 cells.
作者:	李文森 Lee TY;Tsai KL;Lee WS;Hsu C
貢獻者:	醫學科學研究所
日期:	2007
上傳時間:	2009-08-25 09:56:43 (UTC+8)
摘要:	Previously, we showed that predominant expression of the N-methyl-D-aspartate (NMDA) receptor in the neurons of the sexually dimorphic nucleus of the preoptic area of male rats plays an important role in preventing neurons from apoptosis during sexual development. Blocking of the NMDA receptor by dizocilpine ((+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-iminemaleate (MK-801) causes down-regulation of some survival-related genes including cytochrome oxidase subunit II (COII), a mitochondria-encoded complex IV subunit, which in turn induces ATP depletion and the occurrence of apoptosis. The aim of this study is to investigate the molecular events during down-regulation of the COII gene expression induced by blocking of the NMDA receptor. Treatment of the GnRH cell line (GT1-7) with MK-801 caused 1) a decrease of intracellular calcium concentration ([Ca2+]i) after 20 h; 2) significant decreases of the levels of peroxisome proliferator-activated receptor coactivator-1 (PGC-1) mRNA and protein after 24 h; 3) down-regulation of COII mRNA after 36 h; and 4) the occurrence of neuronal apoptosis after 48 h. Accordingly, we hypothesize that blocking of the NMDA receptor may cause a decrease of the [Ca2+]i, which in turn inhibits the expressions of PGC-1 and COII and then leads to subsequent neuronal apoptosis
關聯:	Journal of Molecular Endocrinology.(39):53-66.
資料類型:	article
顯示於類別:	[醫學科學研究所] 期刊論文

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