A pilot study for circadian gene disturbance in dementia patients.

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TMUIR > College of Medicine > Department of Medicine > Department of Neurology > Periodical Article > Item 987654321/3593

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/3593

Title:	A pilot study for circadian gene disturbance in dementia patients.
Authors:	胡朝榮 Liu HC;Hu CJ;Tang YC;Chang JG
Contributors:	醫學系神經學科
Date:	2008
Issue Date:	2009-08-24 17:05:23 (UTC+8)
Abstract:	Disturbance of circadian gene regulation might contribute to behavioral and psychological symptoms in dementia patients. This study was to evaluate the CpG island methylation status on the circadian gene promoters in dementia patients. We conducted a set of methylation specific polymerase chain reaction (mPCR) followed by nucleotide sequencing to analyze the methylation status within the promoters of nine circadian-related genes, including PER1, PER2, PER3, CRY1, CRY2, CLOCK, BMAL1, TIM and CK1epsilon, in the genomic DNA from the peripheral blood leukocytes of 80 dementia patients and 80 age- and gender-matched controls. A total of seven dementia patients (7/80) had CpG island methylation in the circadian genes and none of the controls had methylation. There were three and four patients had CpG island methylation on the promoters of PER1 and CRY1, respectively. Dementia with Lewy body (DLB) patients had the significantly highest frequency of circadian gene CpG island methylation (35.7%). It suggested that epigenetic methylation of circadian gene was more prevalent in dementia patients, especially for the DLB patients. The significance of circadian gene methylation in clinical behavior/sleep disturbance in dementia patients needs further study
Relation:	Neurosci Lett.(435):229-233.
Data Type:	article
Appears in Collections:	[Department of Neurology] Periodical Article

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