Care of a Child with Respiratory Failure due to Type 1 Glutaric Aciduria Treating by Botulin

English | 正體中文 | 简体中文 | Items with full text/Total items : 45422/58598 (78%)
Visitors : 2522563 Online Users : 180

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

TMUIR > College of Medicine > School of Respiratory Therapy > Periodical Article > Item 987654321/3231

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/3231

Title:	Care of a Child with Respiratory Failure due to Type 1 Glutaric Aciduria Treating by Botulin
Authors:	邊苗瑛 Cheng SC;Cheng SH;Su CY;Bien MY;Shie HG
Contributors:	呼吸治療學系
Date:	2008
Issue Date:	2009-08-24 11:31:49 (UTC+8)
Abstract:	戊二酸血症第一型是出生時戊二基輔酶A去氫酶基因(Glutaryl-CoA Dehydrogenase)代謝異常，一種罕見且重要的疾病，最重要的神經症狀包括點、局部或全身的運動障礙與肌肉低張力，治療這些錐體外路症候群，結果通常無法令人滿意，個案係罹患第一型戊二酸血症，以A型肉毒桿菌素治療錐體外路症候群，卻引發呼吸衰竭的合併症。此四歲兒童於每隔六個月注射A型肉毒桿菌素，四次療程後產生呼吸衰竭，主要因呼吸肌肉無力與反覆性吸入性肺炎所引發呼吸衰竭，終至必須長期依賴呼吸器，此類個案以A型肉毒桿菌素治療錐體外路症候群，必須小心注意毒素蓄積的問題。 BACKGROUND: An outline of this rare but important disease, Glutaric aciduria type I is an inborn error of metabolism due to the deficiency of glutaryl-CoA dehydrogenase. The most important neurological symptoms include dyskinesia and dystonia, which can be focal, segmental or generalized. Treatment of the extrapyramidal syndrome is often unsatisfactory. OBJECTIVE: The objective was to describe a case of an Glutaric aciduria type I in the treatment of generalized and focal dystonia with botulinum toxin type A, but induced complication of respiratory failure. METHODS AND MATERIALS: We present a 4-year-old boy who developed respiratory failure after the fourth injection series by botulinum toxin type A. Sixty units of toxin was injected at each series and the intertreatment interval was six months. RESULTS: This ventilatory dependent case was ventilatory muscle weakness and frequency aspiration pneumonia after injection of botulinum toxin type A. CONCLUSION: Our case alerts with the expanding use of botulinum toxin, much concern about the botulinum toxin is arising.
Relation:	Journal of Respiratory Therapy.(7):81-95.
Data Type:	article
Appears in Collections:	[School of Respiratory Therapy] Periodical Article

Files in This Item:

File	Description	Size	Format
全文.txt		0Kb	Text	277	View/Open
摘要.pdf		53Kb	Adobe PDF	272	View/Open

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

Loading...