Taipei Medical University Institutional Repository:Item 987654321/3132
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    Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/3132


    Title: NAT2 fast acetylator genotypes are associated with an increased risk for lung cancer with wildtype epidermal growth factor receptors in Taiwan
    Authors: 劉興璟
    Lee CN;Yu MC;Bai KJ;Chang JH;Fang CL;Hsu HLHuang BS;Lu PC;Liu HE
    Contributors: 臨床醫學研究所
    Identifying the risk factors responsible for lung cancer especially for nonsmokers is critical for both its prevention and treatment. Studies have linked the polymorphisms in N-acetyltransferases (NAT2), a key enzyme for metabolism of hydrocarbons, with lung cancer in Asian female nonsmokers. Since a high percentage of lung adenocarcinoma in Asian female nonsmokers contains activating hotspot mutations in epidermal growth factor receptors (EGFR), we hypothesized that NAT2 polymorphisms might represent a risk factor in lung cancer with EGFR mutations. We studied NAT polymorphisms in 117 nonsmall cell lung cancer (NSCLC) patients and in 119 healthy controls and EGFR hotspot mutations in exons 18-21 in 100 of the 117 patients using polymerase chain reactions. NAT2 fast acetylator genotypes were significantly associated with patients with lung cancer (P = 0.04, odds ratio (OR): 1.90, 95% confidence interval (CI): 1.02-3.57). Further analyses revealed that NAT2 fast acetylator genotypes were significantly associated with NSCLC with wildtype EGFR (P = 0.008, OR: 3.16, 95% CI: 1.31-7.63), but not with those with EGFR mutations (P = 0.40). Therefore, NAT2 fast acetylator genotypes are a potential risk factor especially for lung cancer with wildtype EGFR.
    Date: 2009
    Issue Date: 2009-08-21 16:58:47 (UTC+8)
    Relation: Lung Cancer.(64):9-12.
    Data Type: article
    Appears in Collections:[Graduate Institute of Clinical Medicine] Periodical Article

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