Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation.

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Taipei Medical University Institutional Repository > 醫學院 > 臨床醫學研究所 > 期刊論文 > Item 987654321/3123

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題名:	Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation.
作者:	陳亦仁 Tuan TC;Chang SL;Tai CT;Lin YJ;Hu YF;Lo LW;Wongcharoen W;Udyavar AR;Chiang SJ;Chen YJ;Tsao HM;Ueng KC;Chen SA.
貢獻者:	臨床醫學研究所
日期:	2007
上傳時間:	2009-08-21 16:58:38 (UTC+8)
摘要:	BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. METHODS: This study included 88 patients (age 50 +/- 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. RESULTS: The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 +/- 0.49 vs 2.17 +/- 0.56 mV, P < 0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 +/- 0.67 vs 1.82 +/- 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P < 0.001). CONCLUSIONS: In patients with atrial fibrillation, the RA mean voltage and total activation time were significantly correlated to smoking and had a dose-dependent effect.
關聯:	Journal of cardiovascular electrophysiology.(19):259-265.
資料類型:	article
顯示於類別:	[臨床醫學研究所] 期刊論文

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