Taipei Medical University Institutional Repository:Item 987654321/3117
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    题名: Human mesenchymal stem cells improve myocardial performance in a splenectomized rat model of chronic myocardial infarction.
    作者: 徐國基
    Liu JF;Wang BW;Hung FH;Chang H;Shyu KG
    贡献者: 臨床醫學研究所
    日期: 2008
    上传时间: 2009-08-21 16:58:31 (UTC+8)
    摘要: Background/Purpose: Cellular therapy has been applied to animal studies and clinical trials for acute or
    subacute myocardial infarction. Little is known about the effect of cell therapy on chronic myocardial infarction.
    The goal of this study was to investigate myocardial performance after human bone marrow-derived
    mesenchymal stem cell (hMSCs) transplantation in rats with chronic myocardial infarction.
    Methods: The hMSCs were obtained from adult human bone marrow and expanded in vitro. The purity
    and characteristics of hMSCs were identified by flow cytometry and immunophenotyping. Splenectomy
    in male rats was performed to prevent immune reaction. One week after splenectomy, ligation of the left
    anterior descending coronary artery was performed to induce myocardial infarction. Four weeks after ligation
    of the coronary artery, culture-expanded hMSCs were injected intramyocardially at the left anterior free
    wall. Left ventricular function measured by echocardiography, infarct size and immunohistochemical
    stain were performed to evaluate the effect of the therapy.
    Results: The engrafted hMSCs were positive for the cardiac marker troponin T. Infarct size (35.4 ± 3.4% vs.
    53.3 ± 3.0%, p < 0.001) and fibrotic area (2.6 ± 0.1% vs. 5.9 ± 0.2%, p < 0.001) were significantly smaller in
    the hMSC-treated group than in the control group at 28 days after therapy. hMSC transplantation resulted
    in smaller left ventricular end-diastolic dimension (6.5 ± 0.1mm vs. 7.9 ± 0.7 mm, p < 0.001) and better
    left ventricular ejection fraction (88.7 ± 1.2% vs. 65.8 ± 2.5%, p < 0.001) than in the control group.
    Capillary density was markedly increased after hMSC transplantation compared with the control group.
    Conclusion: This study demonstrates that intramyocardial transplantation of hMSCs improves cardiac
    function after chronic myocardial infarction through enhancement of angiogenesis and myogenesis in the
    ischemic myocardium. Transplantation of hMSCs for myocardial regeneration may become the future
    therapy for chronic myocardial infarction. [J Formos Med Assoc 2008;107(2):165–174]
    關聯: J Formos Med Assoc.(107):165-74.
    数据类型: article
    显示于类别:[臨床醫學研究所] 期刊論文

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