Taipei Medical University Institutional Repository:Item 987654321/2997
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    题名: Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes
    作者: 黃彥華
    Huang YH;Lee TH;Chan KJ;Hsu FL;Wu YC;Lee MH
    贡献者: 醫學系生化學科
    日期: 2008
    上传时间: 2009-08-21 16:33:17 (UTC+8)
    摘要: Melanin is the pigment responsible for skin color. Melanin synthesis occurs with the participation of the tyrosinase (TYR) family of proteins including TYR, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2(TRP2/DCT).

    OBJECTIVE: The effect of a newly isolated natural compound that inhibits hyperpigmentation on the regulation of the TYR family of proteins was examined.

    METHODS: The natural compound, anemonin, was isolated from Clematis crassifolia Benth and was used to inhibit cellular TYR activity; it was found to have a low cytotoxicity (cell viability > 80%) in human melanocytes.

    RESULTS: In human melanocytes, anemonin showed both time- and dose-dependent inhibition (IC(50) 43.5 microM) of TYR. Western blot analysis and immunocytochemical staining revealed that expression of TYR, TRP1, and TRP2 was decreased in anemonin-treated melanocytes. Additionally, reverse transcription and quantitative real-time polymerase chain reaction analyses revealed that expression of mRNAs for MITF, TYR, TYRP1, and TYRP2 was also suppressed by anemonin.

    CONCLUSION: The natural compound, anemonin, an active compound of C. crassifolia, inhibits pigmentation synthesis in human melanocytes. Anemonin inhibits melanin synthesis by inhibiting the transcription of the genes encoding MITF, TYR, TRP1, and TRP2. This natural compound may be a candidate for cosmetic use
    關聯: J. Dermatol. Sci.(49):115-123.
    数据类型: article
    显示于类别:[Department of Biochemistry and Molecular Cell Biology] Periodical Article

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