Static magnetic fields promote osteoblast-like cells differentiation via increasing the membrane rigidity

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Taipei Medical University Institutional Repository > 醫學工程學院 > 生醫材料暨組織工程研究所 > 期刊論文 > Item 987654321/2454

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題名:	Static magnetic fields promote osteoblast-like cells differentiation via increasing the membrane rigidity
作者:	黃豪銘 Chiu KH;Ou KL;Lee SY;Lin CT;Chang WJ;Chen CC;HM Huang
貢獻者:	生醫材料暨工程研究所
日期:	2007
上傳時間:	2009-08-20 12:47:18 (UTC+8)
摘要:	The aim of this study was to test the differentiative effects of osteoblasts after treatment with a static magnetic field (SMF). MG63 osteoblast-like cells were exposed to a 0.4-T SMF. The differentiation markers were assessed by observing the changes in alkaline phosphatase activity and electron microscopy images. Membrane fluidity was used to evaluate alterations in the biophysical properties of the cellular membranes after the SMF simulation. Our results show that SMF exposure increases alkaline phosphatase activity and extracellular matrix release in MG63 cells. On the other hand, MG63 cells exposed to a 0.4-T SMF exhibited a significant increase in fluorescence anisotropy at 6 h, with a significant reduction in the proliferation effects of growth factors noted at 24 h. Based on these findings, the authors suggest that one of the possible mechanisms that SMF affects osteoblastic maturation is by increasing the membrane rigidity and reducing the proliferation-promoting effects of growth factors at the membrane domain.
關聯:	Annal of Biomedical Engineering (in press).(35):1932-1939.
資料類型:	article
顯示於類別:	[生醫材料暨組織工程研究所] 期刊論文

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