Taipei Medical University Institutional Repository:Item 987654321/2404
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    Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/2404


    Title: Absorption and emission spectral shifts of rose bengal associated with DMPC liposomes
    Authors: 楊正昌;蔡翠敏
    Chang CC;Yang YT;Yang JC;Wu HD;Tsai TM
    Contributors: 生醫材料暨工程研究所
    Date: 2008
    Issue Date: 2009-08-20 12:46:41 (UTC+8)
    Abstract: Rose bengal is a water-soluble xanthene dye that is currently used in ophthalmology for the diagnosis of dry eyes. Although the dye is also a potential photosensitizer for photodynamic therapy of tumors, owing to insufficient lipophilicity and tumor accumulation, the clinical application of rose bengal in photodynamic therapy has been hampered. Liposomal encapsulation was seen as a promising approach to overcome these disadvantages, to which end, the spectral properties of the dye in the presence of materials for liposome preparation were studied. The presence of phospholipid influenced the spectral properties of the dye, probably due to the establishment of an equilibrium between monomeric and dimeric forms of the dye, since the photophysical properties of rose bengal depend strongly on its environment. The liposomal encapsulation of the dye generates stronger emission than the free form of the colorant; increased lipid:dye ratio further enhances this emission.

    Keywords: Rose bengal; Liposome; Photosensitizer; Absorption; Emission; Spectrum
    Relation: Dyes and Pigments.(79):170-175.
    Data Type: article
    Appears in Collections:[Graduate Institute of Biomedical Materials and Tissue Engineering] Periodical Article

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