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http://libir.tmu.edu.tw/handle/987654321/23371
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| 題名: | Vitamin C and E supplements improve the impaired antioxidant status and decrease plasma lipid peroxides in hemodialysis patients |
| 作者: | Chao JC, Yuan MD, Chen PY, Chien SW |
| 貢獻者: | Graduate Institute of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan |
| 關鍵詞: | Vitamin C;Vitamin E;Hemodialysis;Antioxidant;Lipid peroxidation |
| 日期: | 2002-05-06 |
| 摘要: | This study investigated the supplementation with vitamin C or/and E on the antioxidant system in hemodialysis patients. Thirty-eight hemodialysis patients (27 males and 11 females) with the average of 60 years old were divided into four groups: placebo (400 mg starch/time), vitamin C (400 mg/time)-, vitamin E (400 mg d,l- alpha-tocopheryl acetate/time)-, and vitamin C (400 mg/time) + E (400 mg d,l- alpha-tocopheryl acetate/time)-supplemented groups for 6-week supplementation. The patients orally received three capsules of placebo or antioxidant(s) three times a week after finishing hemodialysis. Thirty-six healthy subjects (22 males and 14 females) with the average of 58 years old were recruited as the control group. Hemodialysis patients significantly decreased plasma vitamin C by 32%, erythrocyte glutathione by 26%, and plasma total antioxidant status by 9%, but increased plasma lipid peroxide levels by 102% compared with the control group at the baseline. The levels of plasma vitamin C and total antioxidant status significantly decreased by 24% and 18%, respectively, from the post-dialysate compared with those from the pre-dialysate. At week 6, vitamin C + E-supplemented group significantly increased plasma vitamin C and E, erythrocyte glutathione, and plasma antioxidant status, and inhibited plasma lipid peroxides compared with placebo group. Additionally, vitamin C + E-supplemented group had higher plasma vitamin C, vitamin E, and total antioxidant status, and lower plasma lipid peroxides than placebo group even at least 2 weeks after the termination of the supplements. Therefore, antioxidant vitamin supplements could improve antioxidant status and decrease lipid peroxides of hemodialysis patients. |
| 關聯: | J Nutr Biochem 13(11):653-663 |
| 顯示於類別: | [保健營養學系暨研究所] 期刊論文
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| JNB13HD.pdf | 期刊論文 | 1237Kb | Adobe PDF | 194 | 檢視/開啟 |
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