Nationwide surveillance in Taiwan of the in-vitro activity of tigecycline against clinical isolates of extended-spectrum b-lactamase-producing Enterobacteriaceae.

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题名:	Nationwide surveillance in Taiwan of the in-vitro activity of tigecycline against clinical isolates of extended-spectrum b-lactamase-producing Enterobacteriaceae.
作者:	林秀真 Lu CT;Chuang YC;Sun W;Liu YC;Cheng YJ;Lu PL;Chen CM;Hsu GJ;Jang TN;Lee CM;Chiang PC;Shi ZY;Wang LS;Kung HC;Lin HC;Liao CH;Liu JW;Huang CH;Tsao SM;Hsueh PR.
贡献者:	小兒學科
日期:	2008-11
上传时间:	2009-08-10 13:08:28 (UTC+8)
摘要:	Tigecycline In-vitro Surveillance in Taiwan (TIST), initiated in 2006, is a nationwide surveillance programme designed to monitor longitudinally the in-vitro activity of tigecycline against commonly encountered resistant bacteria. This study compared the in-vitro activity of tigecycline against clinical isolates of resistant Gram-negative bacteria determined by the broth microdilution and Etest methods. A total of 622 isolates were collected from patients treated at 20 teaching hospitals. Tigecycline had excellent in-vitro activity against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (N = 275) with MIC(90) 0.5 microg/mL and a 99.6% susceptibility rate, and also against ESBL-producing Klebsiella pneumoniae (N = 324) with MIC(90) 2 microg/mL and a 98.5% susceptibility rate. For ESBL-producing Proteus mirabilis (N = 15) the MIC(90) was 4 microg/mL with a 73.3% susceptibility rate. For ESBL-producing Klebsiella oxytoca (N = 8) the MIC(50) and MIC(90) were 0.5 and 1 microg/mL, respectively, with a 100% susceptibility rate. Limited agreement (<80%) was found between the broth microdilution and the Etest methods when determining the in-vitro activity of tigecycline against ESBL- producing K. pneumoniae and K. oxytoca.
關聯:	International Journal of Antimicrobial Agents.(32):S!79-S183.
数据类型:	article
显示于类别:	[Department of Pediatrics] Original Paper

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