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    題名: Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Diets on Behavior during Lactation and Neonatal Period in Rats
    作者: Yi-Ting Lin;Ming-Jer Shieh;Shih-Yi Huang
    貢獻者: 保健營養學系
    日期: 2009
    上傳時間: 2009-11-17 10:26:25 (UTC+8)
    摘要: RATIONALE & OBJECTIVES:
    Depression is an important disease in the 21st century, especially in women during the pregnancy. Pregnancy and delivery process might give a lots physical stress to women. The aim of this study is to evaluate the effects of eicosapentanoic acid- (EPA) and docosahexaenoic acid-rich (DHA) diets on behavior during lactation and neonatal period in rats.
    MATERIALS & METHODS:
    Sprague-Dawley mother rats (n=8 for each group) were subjected to a diet rich in soy oil, EPA-rich oil or DHA-rich oil during lactation period. After lactation period, mother rats and selected male rat pups were tested in the forced swim test (FST) and determined the lipid composition in plasma and selected areas brain. Other male rat pups (n=8 for each group) were subjected to a diet as same as mother rats for 4 weeks. Behavior performance on the FST and the fatty acid profile from selected tissues were determined.
    RESULTS & FINDINGS:
    The results of the forced swimming test showed that the EPA group had a significantly shorter immobile time than other two groups. The immobile time is negative correlation with the fatty acid profile in plasma C20:5 and prefrontal cortex C22:5. The EPA-rich diet might be impairing the depression-like behavior under the physical stress, but not DHA-rich diet.














    In the results of the fatty acid profile, the prefrontal cortex C22:5 is positive correlation with struggle times and the plasma C20:5 is positive correlation with swim times. In the EPA group, C20:5 and C22:5 are significant changed in blood or prefrontal cortex. The EPA-rich diet might be improving the antidepression-like behaviors under the physical stress. According to these data, it seems to imply the various molecular roles of EPA and DHA under pregnancy stress
    CONCLUSION:
    These observations demonstrate that EPA-rich diet, but not DHA-rich diet, could impair the immobile times and improve the struggle and swim times under physical stress during pregnancy and lactation in mother rats. A similar effect presented in male rat pups both in ablactation and after diet intervention.
    ACKNOWLEDGEMENT:
    The work was supported by the following grants to Dr S.-Y. Huang: 96-2320-B-038-035-MY2 and 98-2320-B-038 -018-MY3 from the National Science Council in Taiwan.
    關聯: 19th International Nutrition Congress (Thailand 2009)
    顯示於類別:[保健營養學系暨研究所] 海報

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