| 摘要: | Aim: A clinical trial was conducted to investigate lipid-lowering and antioxidative effects of combined red yeast rice extract and coenzyme Q10 (CoQ10) supplementation on hypercholesterolemia subjects.
Methods: Thirty-seven subjects were recruited and were randomly divided into three groups such as Monascus rice powder 500 mg (M), equivalent to monacolins 12 mg; Monascus rice powder 500 mg plus CoQ10 30 mg (MQ), and Monascus rice powder 1 g plus CoQ10 60 mg (HMQ) by different doses supplementation. The supplementations administrated for 6 weeks, blood samples were collected every two weeks for cholesterol and low density lipoprotein lag time, and TBARS determination.
Results: Results showed that the subjects had lower serum total cholesterol, LDL cholesterol, and apolipoprotein B concentration after four months of supplementation. In LDL-lag time, the data displayed a significant slower production of conjugated dienes in all groups after six weeks of supplementation. However, in CoQ10 supplementing groups, the effect sustained after ceasing supplementation for two weeks.
Conclusion: The results confirmed the lipid-lowering effects of monacolins by inhibiting HMG CoA reductase and decreasing the concentration apolipoprotein B. Furthermore, addition of at least 30 mg CoQ10 could significantly enhance LDL antioxidative capacity in hypercholesterolemia subjects. |
