Taurine Supplementation Improves the Utilization of Sulfur-Containing Amino Acids in Consecutive Alcohol Administration Rats

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Taipei Medical University Institutional Repository > 營養學院 > 保健營養學系暨研究所 > 海報 > Item 987654321/17986

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題名:	Taurine Supplementation Improves the Utilization of Sulfur-Containing Amino Acids in Consecutive Alcohol Administration Rats
作者:	Hui-Ting Yang;Ching-Chien Chang;Shih-Yi Huang
貢獻者:	保
關鍵詞:	taurine, sulfur-containing amino acids, alcohol, SAM/SAH, pyridoxal 5’-phosphate, homocysteine
日期:	2007
上傳時間:	2009-11-17 10:05:08 (UTC+8)
摘要:	The proposed study is to evaluate the effectiveness of taurine supplementation on the utilization of sulfur-containing amino acid (SCAA) in consecutive alcohol administration rats. Ninety Sprague Dawley rats (male and female 45 each) were consecutively treated with 20% alcohol water solution and taurine (2 g/kg BW taurine) for 4weeks. Food and water were available ad libitum. In the beginning, ten animals (M5, F5) were sacrificed and the biological lesions (blood, brain, and liver) for basal level of SCAAs and other biochemical parameters. The other rats were then sacrificed every week for following four weeks. In results, there is no difference on alcohol-water solution consumption. During the experiment, the plasma alcohol concentration increased during the study, however, taurine-treated animals showed the lower plasma level in week2. Furthermore, homocysteine level of plasma and liver significant elevated in week 2. The plasma SAM/SAH ratio also decreased in week1. On the other hand, the key cofactor of transsulfuration, Vitamin B6, significantly declined in plasma after a week of ethanol intervention whereas and increase was observed in brain tissue. Under the taurine supplementation, some recoveries of SCAA were shown significantly by delaying taurine depletion, increasing SAM/SAH ratio, and elevating plasma and brain level of vitamin B6 in week 2. No biochemical differences between genders were found. In conclusion, taurine supplementation could recover the brain and blood abnormal utilization of SCAA under consecutive alcohol administration in rats.
關聯:	10th Europeon Congress of Nutrition (France 2007)
顯示於類別:	[保健營養學系暨研究所] 海報

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Taurine & SCAA.pdf	125Kb	Adobe PDF	205	檢視/開啟
Taurine & SCAA.ppt	89Kb	Microsoft Powerpoint	417	檢視/開啟
Taurine & SCAA.ps	2820Kb	Postscript	180	檢視/開啟

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