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    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/16679


    題名: Calcium stimulates mitochondrial biogenesis in human granulosa cells.
    作者: 曾啟瑞
    Yeh TS;Ho JD;Yang VWC;Tzeng CR;Hsien RH
    貢獻者: 醫學系婦產學科
    日期: 2005
    上傳時間: 2009-11-13 09:58:51 (UTC+8)
    摘要: Ovarian granulosa cells are known to play a key role in regulating ovarian physiology. Age increases apoptosis in follicular granulosa cells and subsequently decreases ovarian fecundity. The aging ovary also contains fewer follicles that possess fewer granulosa cells. The viability of follicular granulosa cells may be essential for development of the oocyte. Calcium ion plays an important role in a variety of biological processes, including gene expression, cell cycle regulation, and cell death. To study the ability of mitochondrial biogenesis in human granulosa cells, we determined the mitochondrial marker proteins, including the nuclear-encoded NADH-ubiquinone oxidoreductase alpha subunit 9 (NDUFA9) and mitochondrial-encoded COX I, after treatment of the cells with the calcium ionophore A23187. We showed that the expression of these mitochondrial marker proteins in human granulosa cells increased with changes in cytosolic Ca2+ using the ionophore A23187. Treatment of granulosa cells with 0.5 microM of A23187 for 120 h increased the levels of NDUFA 9 and COX I subunit by up to 2.6- and 2.4-fold, respectively. Raising Ca2+ by exposing granulosa cells to 1 microM of A23187 for 48 h significantly increased mitochondrial transcription factor (mtTFA) gene expression by up to 2.9-fold. Our results indicate that the adaptive responses of granulosa cells to increased Ca2+ may include upregulation of mitochondrial proteins and that mtTFA may be involved in such a mitochondrial biogenesis pathway.
    關聯: Ann.N.Y. Acad.Sci.(1042):157-162.
    資料類型: article
    顯示於類別:[婦產學科] 期刊論文

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