Taipei Medical University Institutional Repository:Item 987654321/1561
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    题名: Analysis of the Sesquiterpenoids in Processed Atractylodis Rhizoma
    作者: 王靜瓊;楊玲玲
    Wang KT;Chen LG;Yang LL;Ke WM;Chang HC;Wang CC
    贡献者: 藥學系
    日期: 2007
    上传时间: 2009-08-17 09:55:31 (UTC+8)
    摘要: In Asia, processed Atractylodis Rhizoma, the dried rhizome of Atractylodes ovata De Candolle (Compositae), is widely used as a tonic agent in herbal diets; stir-frying with soil is the most common processing method. In this study, we focused on determining variations in the function and concentrations of sesquiterpenoids in processed Atractylodis Rhizoma. Raw Atractylodis Rhizoma was processed by stir-frying it with different assistant substrates (i.e., red soil and burnt clay). The results indicated that there was less atractylon in stir-fried materials than in raw materials. However, there were higher levels of atractylenolides II and III in stir-fried materials than in raw materials. We also found that the heavy-metal content in burnt clay exceeded regulations set by the Taiwanese government. Moreover, commercial Atractylodis Rhizoma in Taiwan exhibited great differences in concentrations of the active components. In addition, atractylon showed stronger cytotoxicity than atractylenolides II and III in various cell lines. Therefore, we suggest that the toxic effects of atractylon are reduced following atractylon degradation to atractylenolides II and III. In conclusion, the toxicity of Atractylodis Rhizoma is reduced through processing
    關聯: Chem Pharm Bull (Tokyo).(55):50-56.
    数据类型: article
    显示于类别:[藥學系] 期刊論文

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