Antiandrogenic therapy can cause coronary arterial disease (CAD) .

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TMUIR > College of Medicine > Department of Medicine > Department of Urology > Periodical Article > Item 987654321/15615

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/15615

Title:	Antiandrogenic therapy can cause coronary arterial disease (CAD) .
Authors:	陳冠州 Chen KC;Peng CC;Hsieh HM;Peng CH;Hsieh CL;Huang CN;Chyau CC;Wang HE;Peng RY
Contributors:	醫學系泌尿科
Date:	2005
Issue Date:	2009-11-04 11:10:00 (UTC+8)
Abstract:	Aim : To study the change of lipid metabolism by antiandrogen therapy in patients with prostate cancer. Materials and methods : We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II profiles in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN 0 M 0 , Gleason score: 2–5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy. Results : Significant decreases of HDL-C, Apo A-I and Apo A-II and an increase of triglyceride levels in VLDL were induced by CPA. After a period of 2.5 years on CPA treatment, four patients out of twenty-four were found to be affected by coronary heart disease. Conclusions : Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II profiles, other than the well-known hyperglyceridemic effect caused by estrogen.
Relation:	International Journal of Urology.(12):886-891.
Data Type:	article
Appears in Collections:	[Department of Urology] Periodical Article

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