English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 45172/58348 (77%)
造訪人次 : 2465783      線上人數 : 167
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/1555


    題名: A Dose-dependent Pharmacokinetic Study of Levodopa by Intramuscular Administration in Rabbits
    作者: 王莉萱;許光陽
    Wang LS;Hsu KY;Hsu FL;Lin SJ
    貢獻者: 藥學系
    日期: 2008
    上傳時間: 2009-08-17 09:55:28 (UTC+8)
    摘要: 本研究爲將levodopa以肌肉注射方式投予家兔，探討levodopa劑量依存性之藥物動力學。以三種不同劑量的L-dopa/carbidopa (2/0.5, 5/1.25, and 10/2.5 mg/kg)經肌肉注射及一種劑量之L-dopa/carbidopa (2/0.5 mg/kg)經靜脈注射，依交叉試驗方式分別投予六隻雄性兔子，在投藥後採血，取血漿樣品並以高壓液相層析儀分析L-dopa及3-O-methyldopa （levodopa之代謝物，3-OMD）之濃度，經由所得之數據決定L-dopa與3-OMD之藥物動力學之模式。由結果得知，L-dopa經肌肉注射後會被快速吸收，並於30分鐘內達到最高濃度，但3-OMD的形成則較慢，須於120-180分後才達到最高點。L-dopa經肌肉注射後之生體可用率爲0.70-1.21，而3-OMD形成之相對比率爲0.79-1.24；另於不同劑量間，L-dopa之肌肉注射生體可用率及3-OMD形成比率不具統計上的差異。此外，L-dopa與3-OMD於排除半衰期上也不具統計上的差異；而在曲線下面積(AUC)及血漿中最高濃度值(Cmax)，L-dopa與3-OMD於L-dopa/carbidopa在2/0.5-10/2.5 mg/kg劑量範圍內亦呈現正比增加之現象。由此可知，L-dopa與3-OMD在此劑量範圍內無劑量依存性之藥物動力學現象。
    The dose-dependent pharmacokinetics of levodopa (L-dopa) was studied in rabbits by intramuscular administration. Three different doses of L-dopa/carbidopa (2/0.5, 5/1.25, and 10/2.5 mg/kg) were administered to six male rabbits via an intramuscular (IM) route, and one dose of L-dopa/carbidopa (2/0.5 mg/kg) was administered via an intravenous (IV) route with a washout period of 1-week between different doses. Plasma samples were collected after each treatment and the concentrations of L-dopa and 3-O-methyldopa (an L-dopa metabolite, 3-OMD) were measured by a sensitive high-performance liquid chromatographic (HPLC) method. Subsequently, these measurements were used to determine the pharmacokinetic behavior of L-dopa and 3-OMD. The results indicated that the absorption of L-dopa was fast with the time to the peak within 30 min, but the formation of 3-OMD was slow with the time to the peak of 120-180 min after IM administration. The IM bioavailability of L-dopa was in the range of 0.70-1.21, and the relative ratios of the formation of 3-OMD at different doses of L-dopa were in the range of 0.79-1.24. No statistically significant difference could be observed for IM bioavailability of L-dopa or for the relative ratios of the formation of 3-OMD in this dose range. The elimination half-lives of L-dopa and 3-OMD also exhibited no significant differences for each dose after IM administration. In addition, both the area under the curve (AUC) and maximum plasma concentration (Cmax) values of L-dopa and 3-OMD increased proportionally over the dose range of 2/0.5-10/2.5 mg/kg for L-dopa/carbidopa, suggesting that L-dopa and 3-OMD obeyed dose-independent pharmacokinetics.
    關聯: Journal of Food and Drug Analysis.(16):21-27.
    資料類型: article
    顯示於類別:[藥學系] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    171.pdf494KbAdobe PDF97檢視/開啟
    空白.txt0KbText117檢視/開啟


    在TMUIR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    著作權聲明 Copyright Notice

    • 本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。

      The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.

    • 瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。

      By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.

    • 本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。

      TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

    Back to Top
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋