Inhibitory effects of a rice hull constituent on tumor necrosis factor, prostaglandin E2, and cyclooxygenase- 2 production in lipopolysaccharide- activated mouse macrophages.

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Taipei Medical University Institutional Repository > 醫學院 > 醫學系 > 生物化學暨細胞分子生物學科 > 期刊論文 > Item 987654321/13801

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題名:	Inhibitory effects of a rice hull constituent on tumor necrosis factor, prostaglandin E2, and cyclooxygenase- 2 production in lipopolysaccharide- activated mouse macrophages.
作者:	林俊茂;陳建志 Huang ST;Chen CT;Chieng KT;Huang SH;Chiang BH;Wang LF;Kuo HS;Lin CM
貢獻者:	醫學系生化學科
日期:	2005
上傳時間:	2009-10-28 13:56:11 (UTC+8)
關聯:	Ann. NY Acad. Sci.(1042):387-395.
附註:	Isovitexin, isolated from rice hull of Oryza sativa, has been characterized as a potent antioxidant. Its antioxidant activity, determined on the basis of inhibition of lipid peroxidation by the Fenton reaction, was comparable with that of alpha-tocopherol, a well-established antioxidant. Isovitexin was able to reduce the amount of hydrogen peroxide production induced by lipopolysaccharide (LPS) in mouse macrophage RAW264.7 cells. In this study, we assessed its effects on the production of tumor necrosis factor alpha (TNF-alpha), prostaglandin E2 (PGE2), and the expression of cyclooxygenase-2 (COX-2) in LPS-activated RAW 264.7 macrophages. Isovitexin inhibited the release of TNF-alpha, a proinflammatory cytokine, upon LPS activation with a 50% inhibitory concentration (IC50) of 78.6 microM. Isovitexin markedly reduced LPS-stimulated PGE2 production in a concentration-dependent manner, with an IC50 of 80.0 microM. The expression of COX-2 was also inhibited by isovitexin treatment. Our results suggest that suppression of ROS-mediated COX-2 expression by isovitexin is beneficial in reducing inflammation and carcinogenesis.
資料類型:	article
顯示於類別:	[生物化學暨細胞分子生物學科] 期刊論文

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