Effects of n-3 fatty acids on inflammatory mediators and splenocyte cytokine mRNA expressions in rats with polymicrobial sepsis

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Taipei Medical University Institutional Repository > 營養學院 > 保健營養學系暨研究所 > 期刊論文 > Item 987654321/1267

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題名:	Effects of n-3 fatty acids on inflammatory mediators and splenocyte cytokine mRNA expressions in rats with polymicrobial sepsis
作者:	葉松鈴;邱琬淳 Tsou SS;Chiu WC;Yeh CL;Hou YC;Yeh SL
貢獻者:	保健營養學系
日期:	2008
上傳時間:	2009-08-16 21:45:52 (UTC+8)
摘要:	OBJECTIVES: Many studies have shown that omega-3 fatty acids (FAs) have immunomodulatory effects. However, the influence of omega-3 FAs on septic conditions is not certain. This study examined the effect of fish oil (FO)-enriched diets before and/or omega-3 FA-containing total parenteral nutrition (TPN) after sepsis on the distribution of T-lymphocyte subpopulations and splenocyte cytokine mRNA expressions in rats with polymicrobial sepsis. METHODS: Rats were assigned to a control group and four experimental groups. The control group and groups 1 and 2 were fed a semipurified diet, and groups 3 and 4 had 20% soybean oil replaced by FO. After feeding the diets for 10 d, sepsis was induced by cecal ligation and puncture (CLP) in the experimental groups, whereas sham operation was performed on the control group. TPN was maintained for 3 d after CLP or sham operation. The control group and groups 1 and 3 were infused with conventional TPN, whereas the TPN solution of groups 2 and 4 was supplemented with FO. All rats were sacrificed 3 d after the operation to examine their immune responses. RESULTS: Messenger RNA expressions of interleukin-2 and tumor necrosis factor-alpha in splenocytes were higher in groups 3 and 4 than in the control group and group 1. Interleukin-10 mRNA expression in group 3 was higher than in the control group and group 2. Blood CD4 percentage and CD4/CD8 ratio in group 1 were significantly lower, whereas no differences were observed in FO-supplemented groups compared with the control group. CONCLUSION: FO administration before and/or after CLP maintained blood T-lymphocyte subpopulations and modulated T-helper type 1 and 2 cytokine mRNA expressions in rats with polymicrobial sepsis.
關聯:	Nutrition.(24):484-491.
資料類型:	article
顯示於類別:	[保健營養學系暨研究所] 期刊論文

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