Taipei Medical University Institutional Repository:Item 987654321/1261
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    题名: Effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption.
    作者: 楊素卿
    Lin WT;Huang CC;Lin TJ;Chen JR;Shieh MJ;Peng HC;Yang SC;Huang CY
    贡献者: 保健營養學系
    日期: 2009
    上传时间: 2009-08-16 21:45:48 (UTC+8)
    摘要: This study examined the effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption. At the beginning of experiment (week 0), according to both the plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, rats (n = 24) were divided into 3 groups and fed with a standard diet (group C), a diet containing ethanol (group E), or a diet containing ethanol and beta-carotene (group E+B). After 10 weeks, plasma AST and ALT, fat accumulation in the liver, antioxidant enzyme activities in erythrocytes and the liver, malondialdehyde (MDA), and alpha-tocopherol and retinol in plasma and hepatic samples were analyzed. The chronic alcohol diet significantly increased AST and ALT levels in plasma, and these changes were prevented by supplementing the diet with beta-carotene. Glutathione (GSH) in erythrocytes and in the liver was significantly elevated in rats fed with a diet containing beta-carotene. The results indicate that beta-carotene supplementation can prevent ethanol-induced liver damage and increase GSH concentrations in erythrocytes and the liver.
    關聯: Cell Biochemistry and Functtion.
    数据类型: article
    显示于类别:[保健營養學系暨研究所] 期刊論文

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